ĐỐI CHIẾU ĐẶC ĐIỂM LÂM SÀNG VÀ GIẢI PHẪU BỆNH CỦA BỆNH NHÂN VIÊM THẬN LUPUS TRẺ EM

Abstract

Aims: To evaluate the spectrum of pathological findings of pediatric lupus nephritis based on revised ISN/RPS 2018 classification and explore the relationship between these findings and clinical features. Methods and subjects: There are 86 lupus nephritis patients at Children's Hospital 1 from 01/2023 to 03/2024. Results: The most common class was class III (40,7%), other common classes were class IV (31,4%) and class II (25,6%). Class V and mixed classes (III/IV+V) were rare. Activity index (median) = 6 (1-8), chronicity index (median) = 1 (0-2). Immunofluorescence staining with IgG, IgM, C1q was presented in >94% cases. As many as 73,3% of cases feature “full-house” staining for IgG, IgM, IgA, C1q and C3. We found the statistically significant relationship between classes of lupus nephritis and clinical renal manifestations such as urinary abnormalities, nephrotic syndrome, nephritic syndrome and acute kidney injury. Conclusion: Class III nephritis was the most common renal pathology. There was the relationship between clinical and pathological findings in lupus nephritis at the time of kidney biopsy.