Article Sidebar

pdf
Date Published: 18/11/2024
Abstract Views: 79
Views pdf: 53
DOI: https://doi.org/10.51298/vmj.v544i1.11742
Issue
Vol. 544 No. 1 (2024)
Section
Các bài báo
How to Cite
Nguyễn, V. Đề, Nguyễn, B. L., & Phạm, V. T. (2024). CYTOLOGICAL CHARACTERISTICS, IMMUNOHISTOCHEMISTRY AND SOME RELATED FACTORS IN SMALL INTESTINAL GIST PATIENTS Objective: Describe cytological characteristics, immunohistochemistry, and some related factors in small bowel GIST patients at Central Military H. Vietnam Medical Journal, 544(1). https://doi.org/10.51298/vmj.v544i1.11742

CYTOLOGICAL CHARACTERISTICS, IMMUNOHISTOCHEMISTRY AND SOME RELATED FACTORS IN SMALL INTESTINAL GIST PATIENTS Objective: Describe cytological characteristics, immunohistochemistry, and some related factors in small bowel GIST patients at Central Military H

Văn Đề Nguyễn, Bằng Lực Nguyễn, Văn Thịnh Phạm

Main Article Content

Abstract

Objective: Describe cytological characteristics, immunohistochemistry, and some related factors in small bowel GIST patients at Central Military Hospital 108. Methods: A cross-sectional descriptive study combining retrospective and prospective; conducted on 33 patients diagnosed with gastrointestinal stromal tumor in the small intestine, treated surgically at Central Military Hospital 108 from January 2016 to May 2024. Results: 100% of tumors had spindle cell cytology. Low mitoses ≤ 5/50 fields accounted for mainly 60.6%. Immunohistochemical results showed that the CD117 marker accounted for the highest proportion at 97.0%. DOG1 markers account for 93.9%; Ki67 accounts for 75.8%. Low-risk GIST results accounted for the majority, with 54.5%. There is a relationship between the multiplication index and immunohistochemical results. Conclusion: Small intestinal GISTs often have spindle-shaped cytology, mainly positive for markers CD117, DOG1, Ki67.

Article Details

Keywords

cytology, immunohistochemistry, small intestinal gastrointestinal stromal tumor.

References

1. Hirota S., Isozaki K., Moriyama Y., et al. (1998). Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 279(5350): 577-580.
2. Miettinen M., Lasota J. (2006), Gastrointestinal stromal tumors: pathology and prognosis at different sites. In Seminars in diagnostic pathology. Vol. 23. WB Saunders: 70-83.
3. Nguyễn Văn Mão (2011). Đặc điểm mô bệnh học và hóa mô miễn dịch u mô đệm dạ dày ruột ngoài ống tiêu hóa. Tạp chí Y dược học - Trường đại học Y dược Huế, 2: 65-71.
4. National Comprehensive Cancer Network (NCCN) (2024), Gastrointestinal stromal tumor. NCCN Clinical Practice Guidelines in Oncology.
5. Đỗ Hùng Kiên (2017), Nghiên cứu kết quả điều trị u mô đệm đường tiêu hóa (GISTS) giai đoạn muộn bằng imatinib tại bệnh viện K, Luận án tiến sĩ Y học, Trường đại học Y Hà Nội.
6. Sözütek D., Yanık S., Akkoca A. N., et al. (2014). Diagnostic and prognostic roles of DOG1 and Ki-67, in GIST patients with localized or advanced/metastatic disease. International journal of clinical and experimental medicine, 7(7): 1914-22.
7. Kim K. M., Kang D. W., Moon W. S., et al. (2005). Gastrointestinal stromal tumors in Koreans: it's incidence and the clinical, pathologic and immunohistochemical findings. Journal of Korean medical science, 20(6): 977.
8. Iannicelli E., Carbonetti F., Federici G. F., et al. (2017). Evaluation of the relationships between computed tomography features, pathological findings, and prognostic risk assessment in gastrointestinal stromal tumors. Journal of Computer Assisted Tomography, 41(2): 271-278.