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Date Published: 18/11/2024
Abstract Views: 35
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DOI: https://doi.org/10.51298/vmj.v544i1.11761
Issue
Vol. 544 No. 1 (2024)
Section
Các bài báo
How to Cite
Hồ, G. N., Trịnh , T. S., Dương, Đình C., Lê, H., Lê, L. H., Nguyễn, T. H., Nguyễn, H. L., Ngô, V. N. M., & Đặng, T. T. (2024). RESULTS OF EMBRYO CREATION IN IVF CYCLES PERFORMING NON-INVASIVE PRE-IMPLANTATION GENETIC ANALYSIS. Vietnam Medical Journal, 544(1). https://doi.org/10.51298/vmj.v544i1.11761

RESULTS OF EMBRYO CREATION IN IVF CYCLES PERFORMING NON-INVASIVE PRE-IMPLANTATION GENETIC ANALYSIS

Giang Nam Hồ, Thế Sơn Trịnh , Đình Chỉnh Dương, Hoàng Lê, Liên Hương Lê, Thị Hoa Nguyễn, Hữu Lê Nguyễn, Văn Nhật Minh Ngô, Tiến Trường Đặng

Main Article Content

Abstract

Objective: To evaluate the results of embryo formation in in vitro fertilization cycles using non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A). Subjects and methods: A cross-sectional observational study of 44 couples who were indicated for preimplantation genetic testing for aneuploidy (PGT-A) and NiPGT-A who volunteered to participate in the study from 2020-2024 at Tam Anh General Hospital - Hanoi, and were cultured using a single-drop culture procedure. Results: The average age of the wife was 35 ± 4.68; infertility 2 accounted for 86.4%; PGT-A and NiPGT-A were indicated mainly due to advanced maternal age (43.2%) and chromosomal abnormalities of the wife or husband (20.5%); The average AMH was 2.99 ± 2.11 (ng/ml), FSH 6.83 ± 2.12 (mIU/ml), LH 5.25 ± 2.27 (mIU/ml), E2 34.73 ± 12.33(mIU/ml), P4: 0.23 ± 0.25(mIU/ml), Prolactin 53.36 ± 108.81; The average number of secondary follicles was 17.25 ± 11.59; The total FSH dose used in the controlled ovarian stimulation cycle was 2817.32 ± 366.46IU, the average FSH use time was 9.91 ± 0.77 days; The average number of aspirated follicle complexes was 11.73 ± 7.13 complexes; MII oocytes 8.73 ± 5.76; fertilization rate was 89 ± 14.5%; day 3 cleavage embryo rate was 90 ± 13%, blastocyst formation rate was 90 ± 14%; day 3 cleavage embryo transfer rate to blastocyst stage was 99.2% ± 5%. Conclusion: High fertilization results reached 89% ± 14.5% and blastocyst formation results were 90.1 ± 14.5% (total 344 blastocysts); day 3 cleavage embryo transfer rate to blastocyst stage was 99.2% ± 5%. Adjusting the single-drop embryo transfer process has increased the successful transfer rate of embryo transfer from day 3 cleavage embryo to blastocyst stage, ensuring non-invasive preimplantation genetic testing.

Article Details

Keywords

individual embryo culture, in vitro fertilization, niPGT, noninvasive pre-implantation genetic testing.

References

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