ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ BIỂU LỘ PD-L1 Ở BỆNH NHÂN UNG THƯ PHỔI TẾ BÀO NHỎ TẠI BỆNH VIỆN QUÂN Y 103

Abstract

Objective: To describe clinical, paraclinical characteristics and mPD-L1 expression in small cell lung cancer patients at Military Hospital 103. Subjects and methods: A Prospective, cross-sectional study on 30 small cell lung cancer patients diagnosed by immunohistochemistry, inpatient treatment at the Respiratory Center, Military Hospital 103 from January 2022 to October 2024. Patients were examined clinically, paraclinically and expressed mPD-L1 on tissue samples tested. Results: Patients have a high average age (69.61 ± 7.17 years old), most commonly aged from 61 to 70 (53.33%). 100% of patients are men, with 93.33% smoker. The most common subjective symptom is cough (86.67%), following by chest pain (53.33%), sputum (46.67%), dyspnea (36.67%) and hemoptysis (23.33%). The proportion of pleural effusion is quite high (26.67%). Tumors are usually in the upper lobes on both sides (60%), centrally located (96.67%), and larger than 3 cm in size (86.67%), with jagged edges (100%), and destroyed (30%). 83.33% of patients are in the widespread stage. 100% of patients have negative mPD-L1 expression. Conclusions: Patients with small cell lung cancer are usually male, high age, having a history of smoking, diverse clinical symptoms, upper lobe center tumors with large size, late disease stage, and negative expression of mPD- L1