EVALUATE THE RESULTSOF MD-COLLAGEN INJECTION THERAPY UNDER ULTRASOUND GUIDANCEIN THE TREATMENT OF SUPRASPINATUS TENDONITIS

Đặng Chí Hiếu1, Nguyễn Vĩnh Ngọc2,
1 E Hospital
2 Hanoi Medical University

Main Article Content

Abstract

Aims: Evaluate the results of MD-collagen injection therapy in the treatment of supraspinatus tendonitis under ultrasound guidance and evaluate adverse effects of this therapy after 12 weeks of follow-up. Methods: Controlled clinical trial were followed up to 12 weeks in 61 patients with supraspinatus tendonitis,divided into two groups: 30 patients received 5 times in 5 consecutive weeks’sultrasound-guided injection of Collagen MD-Shoulderinto the subacromial bursa, 31 patientswere given a single ultrasound-guided injection of Depo-Medrolinto the subacromial bursa. Results: After 12 weeks of treatment, there was an improvement in VAS, OSS scores, shoulder range of motion in the research group: The average VAS were decreased from 6.8 to 2.5 points (reduction rate compared to T0 is 63.9%.), OSS scores were increased from 23,5 ± 4,9 to 39,7 ± 6,9 points (the rate of increase compared to T0 is 39.4%)higher than the placebo group (p<0,05), shoulder range of motion increased from 147,83 to 171,30 (the rate of increase compared to T0 is 20,6%). Side effects of the research group was 13.3% of the patients increased pain at the injection. Conclusion: MD-Shoulder collagen injection therapy under ultrasound guidance in the treatment of supraspinatus tendonitis has the effect of reducing pain, improving motor function and angle of motion after 12 weeks of treatment. Ultrasound-guided MD-Shoulder Collagen Injection therapy had similar analgesic effect, but improved shoulder mobility better than Depo-Medrol injection therapy from 5 weeks, lasting up to 12 weeks of treatment (p < 0.05).

Article Details

References

1. Trần Ngọc Ân. Viêm quanh khớp vai. Bệnh Thấp khớp. Nhà xuất bản Y Học 2002:364 - 374.
2. Rockwood CA, Matsen FA. The Shoulder. Saunders; 1990.
3. Lipman K, Wang C, Ting K, Soo C, Zheng Z. Tendinopathy: injury, repair, and current exploration. Drug design, development and therapy. 2018;12:591-603. doi:10.2147/ dddt.S154660
4. Dean BJ, Lostis E, Oakley T, Rombach I, Morrey ME, Carr AJ. The risks and benefits of glucocorticoid treatment for tendinopathy: a systematic review of the effects of local glucocorticoid on tendon. Seminars in arthritis and rheumatism. Feb 2014;43(4):570-6. doi:10.1016/j. semarthrit.2013.08.006
5. Friedrichs J, Taubenberger A, Franz CM, Muller DJ. Cellular remodelling of individual collagen fibrils visualized by time-lapse AFM. Journal of molecular biology. Sep 21 2007;372(3): 594-607. doi:10.1016/j.jmb.2007.06.078
6. Nestorova R, Rashkov R. Collagen injections Guna MDs in patients with acute periarthritis of the shoulder: clinical and sonographic assessment. 2013:S135-S136.
7. Nguyễn Quanh Quyền, Phạm Văn Diệu. Atlas giải phẫu người, tài liệu dịch của tác giả Netter Frank H. NXB Y học 2007; 2007.
8. Rincón-Hurtado Á M, Rocha-Buelvas A, López-Cardona A, Martínez JW. Health-related quality of life of patients with rotator cuff injuries, Cofee Triangle, Colombia, 2013. Revista brasileira de ortopedia. May-Jun 2018;53(3):364-372. doi:10.1016/j.rboe.2018.03.018
9. Corrado B, Bonini I, Chirico VA, et al. Ultrasound-guided collagen injections in the treatment of supraspinatus tendinopathy: a case series pilot study. Journal of biological regulators and homeostatic agents. May-Jun 2020;34(3 Suppl. 2):33-39. advances in musculoskeletal diseases and infections - sotimi 2019.