PHÂN TÍCH ĐẶC ĐIỂM DÙNG THUỐC VÀ CÁC YẾU TỐ ẢNH HƯỞNG ĐẾN HIỆU QUẢ ĐIỀU TRỊ NHIỄM KHUẨN HUYẾT TẠI KHOA ICU BỆNH VIỆN ĐỒNG NAI - 2

Abstract

Background: Sepsis is a common cause of death in intensive care units and intensive care units (ICUs) worldwide. Timely antibiotic treatment is the cornerstone of ICU infection. Objectives: The aim of this study is to investigate the use of antibiotics and related factors affecting the treatment effectiveness of sepsis at ICUs. Methods: A descriptive cross-sectional study was conducted on 106 medical records of patients diagnosed with sepsis from January, 2023 to February, 2024 in ICU departments of Đồng Nai - 2 hospital. Results: There were 106 patients diagnosed with sepsis or septic shock included in the study. Demographic data, comorbid diseases, clinical and laboratory data were collected prospectively. Patients had an average age of 72 years old, men: 56,6%. The most common cause is from respiratory infections. Hypertension is the majority of comorbid diseases. The majority of patients were prescribed empirical regimens based on piperacillin-tazobactam or C3G/C4G or carbapenem to treat sepsis or septic shock at rates of 41,5%, 22,6% and 25,5%, respectively. After the results of the antibiogram were available, the rate of carbapenem-based combinations doubled (55,4%). The proportion of colistin-based combinations also increased significantly (25%). Adherence to treatment according to recommendations of the Sanford Guide (2018) and the Toxic Resuscitation Association (2020) of the empirical antibiotic group was 32,1% and 56,6% and the group based on antibiogram results was 46,4% and 50,9%.The treatment adherence to the Sanford Guide and the number of comorbidities has a significant impact on the effectiveness of treatment. Conclusion: Antibiotics should be used with caution to avoid resistance. The study findings suggested that clinicians should appropriately adhere to antimicrobial guidelines and susceptibility test.