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MICROBIAL EFFICACY OF FULL-MOUTH SCALING AND ROOT PLANING COMBINED WITH AMOXICILLIN AND METRONIDAZOLE IN THE TREATMENT OF SEVERE PERIODONTITIS CASES
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Abstract
Purpose: To evaluate the effectiveness of combining Amoxicillin (AMX) and Metronidazole (MET) antibiotics in supporting full-mouth scaling and root planning (SRP) for patients with Stage III/IV periodontitis. Materials and methods: Sixteen patients with Stage III/IV periodontitis, aged 18 to 40 years, underwent SRP within 24-48 hours combined with AMX (500 mg, three times daily) and MET (400 mg, three times daily) for 3 days. Subgingival plaque samples were assessed for four bacteria Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), and Fusobacterium nucleatum (Fn) using Real-Time PCR at three time-points: baseline (T0), 4th (T4) and 8 th (T8) weeks after treatment. Result: After intervention, all four bacteria (Pg, Tf, Td, and Fn) showed significant reductions, particularly for the three bacteria in the red complex, with statistically significant differences observed between T4 and T0 (p<0.01) and T8 and T0 (p<0.05). For Fn, statistically significant differences were only found between T0 and T8 (p<0.05). No significant differences were found between T4 and T8 for all studied bacteria. Conclusion: Full-mouth SRP combined with AMX and MET is effective in reducing the periodontal pathogens in patients with Stage III/IV periodontitis, and this effect could be maintained 8 weeks.
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Keywords
: Full-mouth scaling and root planing, Periodontitis, Amoxicillin, Metronidazole.
References
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