TỈ SỐ ASPARTATE AMINOTRANSFERASE (AST)/ ALANINE AMINOTRANSFERASE (ALT) VÀ MỘT SỐ BỆNH MẠN TÍNH Ở NGƯỜI DƯỚI 60 TUỔI CÓ HỘI CHỨNG CHUYỂN HÓA

Abstract

Background: The enzymes AST (aspartate aminotransferase) and ALT (alanine aminotransferase) are frequently elevated in cases of non-alcoholic fatty liver disease and are linked to metabolic syndrome (MetS). Nevertheless, there is insufficient evidence regarding variations in the AST/ALT ratio across different chronic diseases in individuals under 60 years old with MetS. Method: Adults from 18 to under 60 years old, diagnosed with metabolic syndrome according to the criteria of NCEP ATP III 2001 and coming for examination or outpatient treatment at Le Van Thinh hospital from January to May 2024, will be selected for the study. Data on AST, ALT levels, and chronic diseases will be collected from this group of subjects. Results: The study comprised 120 participants with an average age of 50.9±6.7 years, predominantly male. The most common chronic conditions observed were dyslipidemia, hypertension, gout, diabetes, and fatty liver, with prevalence rates of 67.5%, 62.5%, 43.3%, 40%, and 33.9%, respectively. There were significant differences in the AST/ALT ratio in cases of fatty liver, dyslipidemia, and gout (highest at the 3rd percentile) with p-value <0.05. Additionally, the AST/ALT ratio showed a negative correlation with BMI and triglycerides (r = -0.24, p<0.001) and a positive correlation with serum creatinine (r = 0.44, p = 0.007). Conclusion: The AST/ALT ratio is related to some chronic diseases in adults under 60 years old with metabolic syndrome.