LYMPHATIC MAGNETIC RESONANCE IMAGING FINDINGS IN PATIENTS WITH CHYLURIA

Tiến Mạnh Nguyễn, Ngọc Cương Nguyễn, Tuấn Linh Lê

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Abstract

Overview: Chyluria is a common manifestation of lymphatic system lesion, caused by communication between lymphatic branches and the urinary system. Object: To evaluate the characteristics of magnetic resonance imaging (MRI) of the lymphatic system with the injection of paramagnetic contrast agents through the inguinal lymph nodes to identify the cause and the location of the lesion. Subjects and methods: The study was conducted on 41 patients diagnosed with chyluria through clinical examination, cystoscopy and urinary triglyceride testing. All patients underwent magnetic resonance imaging of the lymphatic system with the injection of paramagnetic contrast agents through the inguinal lymph nodes. Results: The average age of 65,9 years, with a male to female ratio of 1:2. Magnetic resonance imaging showed 100% visualization of the lumbar lymphatic trunk, thoracic duct, 92.8% of the urinary bladder, and detected 97.6% of patients with fistula branches into the renal pelvis, of which the majority of patients had communication of lymphatic branches into the left renal pelvis with 56.1%. In terms of the ability to detect fistula, MRI compared to cystoscopy had a sensitivity of 100%, a specificity of 25%, a positive predictive value of 92.5%, and a negative predictive value of 100%. In terms of the ability to detect fistula, MRI compared to Digital subtraction lymphagiography (DSA) had a sensitivity and specificity of 100%, a positive predictive value of 100% and a negative predictive value of 100%.

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References

1. Dori Y, Zviman MM, Itkin M. Dynamic contrast-enhanced MR lymphangiography: feasibility study in swine. Radiology. Nov 2014;273(2):410-6. doi:10.1148/radiol.14132616
2. Wang L, Chi J, Li S, Hua X, Tang H, Lu Q. Magnetic resonance lymphangiography in recurrent chylous ascites and chyluria. Kidney Int. Jun 2017;91(6): 1522. doi:10.1016/j.kint. 2016.12.026
3. Singh I, Dargan P, Sharma N. Chyluria - a clinical and diagnostic stepladder algorithm with review of literature. Indian Journal of Urology. 2004;20(2):79-85.
4. Stainer V, Jones P, Juliebø S, Beck R, Hawary A. Chyluria: what does the clinician need to know? Ther Adv Urol. Jan-Dec 2020;12:1 756287220940899. doi:10.1177/ 1756287220940899
5. Sabbah A, Koumako C, El Mouhadi S, et al. Chyluria: non-enhanced MR lymphography. Insights into Imaging. 2023/07/05 2023; 14(1):119. doi:10.1186/s13244-023-01461-2
6. Hoa T, Cuong N, Hoan N, et al. Central Lymphatic Imaging in Adults with Spontaneous Chyluria. International Journal of General Medicine. 05/29 2024;17: 2489-2495. doi:10. 2147/IJGM.S459768
7. Pimpalwar S, Chinnadurai P, Chau A, et al. Dynamic contrast enhanced magnetic resonance lymphangiography: Categorization of imaging findings and correlation with patient management. Eur J Radiol. Apr 2018;101:129-135. doi:10.1016/j.ejrad.2018.02.021
8. Lovrec Krstić T, Šoštarič K, Caf P, Žerdin M. The Case of a 15-Year-Old With Non-Parasitic Chyluria. Cureus. Aug 2021;13(8):e17388. doi:10.7759/cureus.17388
9. Munn LL, Padera TP. Imaging the lymphatic system. Microvasc Res. Nov 2014;96:55-63. doi:10.1016/j.mvr.2014.06.006
10. Ramirez-Suarez KI, Tierradentro-Garcia LO, Smith CL, et al. Dynamic contrast-enhanced magnetic resonance lymphangiography. Pediatr Radiol. Feb 2022;52(2): 285-294. doi:10.1007/ s00247-021-05051-6