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RESEARCH OF MMP-2 CONCENTRATIONS IN THE PLASMA OF PREECLAMPTIC PREGNANT WOMEN
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Abstract
Objectives: The study aims to evaluate the plasma concentration of matrix metalloproteinase-2 (MMP-2) in healthy pregnant women and those with preeclampsia, and to investigate the relationship between MMP-2 levels and specific clinical and paraclinical parameters in preeclamptic patients. Subjects and Methods: The research was conducted at Hanoi Obstetrics and Gynecology Hospital and included two cohorts: 120 healthy pregnant women (control group) and 120 preeclamptic pregnant women (patient group). Plasma MMP-2 levels were measured using a quantitative enzyme-linked immunosorbent assay (ELISA) method. Results: The mean plasma concentration of MMP-2 in the preeclamptic group was 486.19 ± 280.15 ng/mL, significantly higher than the 314.67 ± 180.44 ng/mL observed in the control group (p < 0.001). A statistically significant positive correlation was identified between MMP-2 levels and systolic blood pressure (R = 0.197, p = 0.031), while a negative correlation was found between MMP-2 levels and platelet count (R = -0.201, p = 0.027). Conclusion: Elevated plasma MMP-2 concentrations were observed in preeclamptic women compared to their healthy counterparts. MMP-2 levels were positively associated with systolic blood pressure and negatively associated with platelet count in preeclamptic women.
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Keywords
Pre-eclampsia, Matrix Metalloproteinase (MMP), MMP-2
References
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