MỘT SỐ YẾU TỐ ẢNH HƯỞNG ĐẾN KẾT QUẢ HÓA CHẤT DẪN ĐẦU PHÁC ĐỒ TCF THEO SAU BỞI HÓA XẠ TRỊ UNG THƯ VÒM MŨI HỌNG GIAI ĐOẠN III-IVA TẠI BỆNH VIỆN K

Abstract

Objective: To evaluate certain factors affecting the treatment outcomes of TCF induction chemotherapy followed by concurrent chemoradiotherapy in patients with stage III-IVA nasopharyngeal carcinoma at Vietnam National Cancer Hospital. Subjects and Methods: A retrospective descriptive study was conducted on 40 patients diagnosed with stage III-IVA nasopharyngeal carcinoma, who received TCF induction chemotherapy followed by concurrent chemoradiotherapy at Vietnam National Cancer Hospital from January 2019 to December 2020. Results: The 3-year progression-free survival (PFS) and overall survival (OS) rates were 77.5% and 87.5%, respectively. The 3-year PFS for stage III patients was significantly higher compared to stage IV patients (76.3% versus 50%), p = 0.031. Disease stage was an independent prognostic factor. Age, radiotherapy techniques, and treatment response did not statistically significantly affect PFS and OS. Conclusion: For patients with stage III and IVA nasopharyngeal carcinoma, TCF induction chemotherapy followed by concurrent chemoradiotherapy is an appropriate treatment option with relatively high survival outcomes. Disease stage is an independent prognostic factor influencing treatment outcomes.