KHẢO SÁT TÌNH HÌNH SỬ DỤNG KHÁNG SINH VÀ CÁC YẾU TỐ LIÊN QUAN ĐẾN HIỆU QUẢ ĐIỀU TRỊ VIÊM PHỔI CỘNG ĐỒNG Ở TRẺ EM

Abstract

Introduction: Antimicrobial therapies are the main treatment for Community-acquired pneumonia (CAP) in children. Nowadays, the high ratio of multidrug-resistant bacteria leads to updating the actual antibiotical usage to control and use antibiotics safely as well as effectively. Objectives: To study the use of mono and combination therapy, related factors of the effectiveness of the CAP treatment in children from 2-60 months of age. Materials and methods: A cross-sectional, retrospective study on 360 medical records of children hospitalized from September 2018 to September 2019 was conducted at some hospitals in Quang Nam province. Results and discussions: Mono-therapy with β-lactams (92.6%) predominates over combination therapy. Among the monotherapy, amoxicillin has the highest frequency of use (25.2%). Combination therapy with beta-lactam and macrolide accounted for the highest rate (53.7%) compared with other combinations. The rate of antibiotic use with an appropriate dose and timing administration was 81.4% and 94.4%, respectively. The success rate of CAP treatment reached 89.2% within the first 48-72 hours. The factors influencing the effectiveness of the treatment include the history of the patient, the severity of disease, the history of antibiotic use, and the appropriateness of the dose. Conclusions: In general, the indications of antibiotic therapy, dosage, and timing administration in hospitals are mostly under current guidelines. Factors affecting treatment effectiveness within 48-72 hours should be taken into consideration to improve patient outcomes.