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BISPHOSPHONATE INDUCED OSTEONECROSIS OF THE JAWS: CLINICAL CASE FOLLOWED- UP AFTER 5 YEARS
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Abstract
Bisphosphonate is a group of drugs used to treat osteoporosis, multiple myeloma, skeletal metastasis cancer. BP's mechanism of action is to reduce bone resorption by inhibiting the osteoclasts activity. Therefore, the indication of BP is increasingly widespread and becomes the first class of drugs in the treatment of osteoporosis. However, in 2003 Marx reported for the first time a clinical case of bisphosphonate induced osteonecrosis of the jaws (BIONJ). Since then, an increasing number of reported cases of osteonecrosis are associated with BP. In this report, we describe two cases of an 85-year-old female patient and a 61-year-old female patient diagnosed with BIONJ. The patient was diagnosed with osteoporosis and treated by Fosamax for 4,5 consecutive years.
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Keywords
Bisphosphonate, bisphosphonate induced osteonecrosis of the jaws (BIONJ)
References
2. Marx, R.E, and R.Tursun. "Suppurative osteomyelitis, bisphosphonate induced osteonecrosis, osteoradionecrosis: a blinded histopathologic comparison and its implications for the mechanism of each disease." International journal of oral and maxillofacial surgery
41.3 (2012): 283-289.
3. McLeod, Niall MH, PeterA. Brennan, and Salvatore L.Ruggiero. "Bisphosphonate osteonecrosis of the jaw: a historical and contemporary review." The Surgeon 10.1 (2012): 36-42.
4. Rodan GA, Fleisch HA. Bisphosphonates: mechanisms of action. The Journal of clinical investigation, 1996.
5. Ruggiero L.S, Dodson T.B, Assael L.A. American association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws- 2009 update. J Oral Maxillofac Surg 2009; 67: 2- 12.
6. Ruggiero L.S., Fantasia J., Carlson E. Bisphophonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Radiol Endod 2006; 102(4):433-441.
7. Wilde, Frank, et al. "The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw."Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 111.2 (2011): 153-163.
8. Yamazaki T, Yamori M, Ishizaki T, Asai K, Goto K, Takahashi K, Nakayama K, Bessho K, Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. International Journal of Oral and Maxillofacial Surgery.Volume 41,Issue 11,2012, Pages 1397-1403,ISSN 0901-5027.
9. Sandeep Kalraa and Veena Jainb, Dental complications and management of patients on bisphosphonate therapy: A review article. Journal of Oral Biology and Craniofacial Research. 2013 Jan-Apr; 3(1): 25–30.