SURVEY OF PLASMA KLOTHO CONCENTRATIONS IN MAINTENANCE HEMODIALYSIS PATIENTS
Main Article Content
Abstract
Objective: To investigate plasma Klotho concentration and its relationship with some clinical and paraclinical characteristics in maintenance hemodialysis patients. Research methods: The study subjects included 84 people, divided into 2 groups: the disease group (n=44) were maintenance hemodialysis patients, the control group (n=40) were healthy people of similar age and gender. Plasma Klotho levels were quantified using the ELISA method in all subjects. The disease group was explored for clinical and paraclinical manifestations, cardiovascular events, and carotid Doppler ultrasound was performed to measure intima-media thickness and determine atherosclerosis status. Results: Average age was 38.7 ± 11.85 years old, male accounted for 65.9%, average hemodialysis duration was 12 months. The average plasma Klotho concentration in the disease group was 1.06 ± 0.28 ng/mL, lower than the control group: 1.08 ± 0.3 ng/mL, p> 0.05. Low plasma Klotho levels are associated with hypertension, increased CRP, carotid artery intima-media thickening and increased cardiovascular events, p < 0.05. Conclusion: Plasma Klotho is a factor related to atherosclerosis and cardiovascular events in maintenance hemodialysis patients.
Article Details
Keywords
End-stage kidney disease, maintenance hemodialysis, plasma Klotho, atherosclerosis.
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