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Date Published: 18/10/2021
Abstract Views: 184
Views PDF: 104
DOI: https://doi.org/10.51298/vmj.v506i1.1207
Issue
Vol. 506 No. 1 (2021)
Section
Các bài báo
How to Cite
Đình Châu, N. ., & Ngọc Hà, L. . (2021). PROGNOSTIC ROLE OF 18F-FDG PET/CT STANDARD UPTAKE VALUES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA PATIENTS TREATED WITH DEFINITIVE CHEMORADIOTHERAPY. Vietnam Medical Journal, 506(1). https://doi.org/10.51298/vmj.v506i1.1207

PROGNOSTIC ROLE OF 18F-FDG PET/CT STANDARD UPTAKE VALUES IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA PATIENTS TREATED WITH DEFINITIVE CHEMORADIOTHERAPY

Nguyễn Đình Châu1,, Lê Ngọc Hà1
1 108 Military Central Hospital

Main Article Content

Abstract

Objectives: The aim of this study was to investigate whether standard uptake values (SUV) of pre-treatment 18F-FDG PET/CT were helpful for predicting the outcomes in esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy. Materials and methods: Sixty patients with esophageal squamous cell carcinoma who underwent 18F-FDG PET/CT and received definitive chemoradiotherapy. 18F-FDG SUVs of tumor including SUVmax, SUVmean, SUVpeak were calculated. The receiver operating characteristic curve (ROC) was used to determine the optimal SUVs cut-off value that associated with response and survival. Using Kaplan-Meier for overall survival (OS) and progression-free survival (PFS) analysis. Multivariate analysis of survival was performed using Cox regression.  Results: Complete response was achieved in 38,3%. The 4-year overall survival (OS) and progression-free survival (PFS) rates were 48.6% and 44.4%, respectively. SUVmean with a cut-off value of 6.1 could predict complete response with sensitivity of 69.6%, specificity of 78.4%, and accuracy of 75%. SUVmean > 6.1 was a unfavorable prognostic factor for OS (HR = 6,74, p = 0.02) and PFS (HR = 6.53, p = 0.00). Conclusions: Our study suggests that SUVmean of the primary tumor in pretreatment 18F-FDG PET/CT may be used in predicting the outcomes for esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.

Article Details

Keywords

18F-FDG PET/CT, standard uptake values (SUVs), ), esophageal squamous cell carcinoma

References

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