IMAGING CHARACTERISTICS OF ARTERIAL SPIN LABEL SEQUENCES IN THE DIAGNOSIS OF ACUTE CEREBRAL INFARCTION WITH GREAT ARTERY OCCLUSION AT HANOI MEDICAL UNIVERSITY HOSPITAL
Main Article Content
Abstract
Objective: To describe the characteristics of ASL MRI perfusion imaging in the diagnosis of acute cerebral infarction with large artery occlusion. Subject and method: A cross-sectional descriptive study on 40 patients with acute with cerebral infarction and large artery occlusion at Hanoi Medical University Hospital. Patients underwent MRI with conventional pulse sequences, DWI/ADC pulse sequences and ASL to assess the lesion area. Result: Mean age was 68,23 ± 13.33, the lowest was 30, the highest was 92 with 55% being male. MRI scan between 6-24 hours accounted for 43.59%. There was a significant difference between the mean CBF of the infarct core (10.05 ± 2.87 ml/100g/min), ischemic penumbra (15.59 ± 4.11 ml/100g/min) and the contralateral healthy region (35.47 ± 13.67 ml/100g/min). Conclusion: ASL pulse sequence does not require contrast injection but still helps to identify the ischemic penumbra, complements the DWI pulse sequence to diagnose early infarction, and supports the clinical decision-making process.
Article Details
Keywords
cerebral perfusion pulse sequence, magnetic resonance, acute cerebral infarction
References

2. Murphy, S. JX. & Werring, D. J. Stroke: causes and clinical features. Medicine (Abingdon) 48, 561–566 (2020).

3. Smith, W. S., Johnston, S. C. & Hemphill, I., J. Claude. Cerebrovascular Diseases. in Harrison’s Principles of Internal Medicine (eds. Jameson, J. L. et al.) (McGraw-Hill Education, New York, NY, 2018).

4. Peters, S. A. E., Carcel, C., Millett, E. R. C. & Woodward, M. Sex differences in the association between major risk factors and the risk of stroke in the UK Biobank cohort study. Neurology 95, e2715–e2726 (2020).

5. Saver, J. L. Time is brain--quantified. Stroke 37, 263–266 (2006).

6. Heiss, W.-D. & Zaro Weber, O. Validation of MRI Determination of the Penumbra by PET Measurements in Ischemic Stroke. J Nucl Med 58, 187–193 (2017).

7. Ma, X. et al. Evaluation of infarct core and ischemic penumbra by absolute quantitative cerebral dynamic susceptibility contrast perfusion magnetic resonance imaging using self-calibrated echo planar imaging sequencing in patients with acute ischemic stroke. Quantitative Imaging in Medicine and Surgery 12, 4286295–4284295 (2022).

8. ASL perfusion in acute ischemic stroke: The value of CBF in outcome prediction - ScienceDirect. https://www.sciencedirect.com/ science/article/abs/pii/S0303846720302511.
