Article Sidebar

PDF
Date Published: 18/10/2021
Abstract Views: 431
Views PDF: 268
DOI: https://doi.org/10.51298/vmj.v506i1.1214
Issue
Vol. 506 No. 1 (2021)
Section
Các bài báo
How to Cite
Thị Thanh Ngà, L., Văn Dũng, H. ., & Hoài Nam, N. . (2021). THE CHARACTERISTICS OF GASTRODUODENAL INJURY IN RHEUMATOID ARTHRITIS PATIENTS USED GLUCOCORTICOID. Vietnam Medical Journal, 506(1). https://doi.org/10.51298/vmj.v506i1.1214

THE CHARACTERISTICS OF GASTRODUODENAL INJURY IN RHEUMATOID ARTHRITIS PATIENTS USED GLUCOCORTICOID

Lê Thị Thanh Ngà1,, Hoàng Văn Dũng2, Nguyễn Hoài Nam3
1 Hanoi Medical University
2 Hai Phong International General Hospital
3 Bach Mai Hospital

Main Article Content

Abstract

Objective: Describe the characteristics of gastrodoudenal injury based on the modified Lanza score in rheumatoid arthritis patients used glucocorticoid. Subjects and methods: 55 rheumatoid arthritis patients, who treated with glucocorticoid, underwent gastrointestinal endoscope. All patients were surveyed for characteristics of rheumatoid arthritis, glucocorticoid using (GC) and gastroscopy - duodenum assessed for gastric lesions based on the modified Lanza score. Result: The average age was 56,09 ± 12,17 years (28 ÷ 76), the disease duration was 54,65 months (1 ÷ 240), DAS28 – CRP was 4,04 ± 1,34. 40% of patients had clinical symptoms of the gastrointestinal tract and The prevalence of gastrodoudenal injury was 18,2% of patients had gastroduodenal injury on gastroduodenal endoscopy, the modified Lanza score was 0,6 ± 1,396. Conclusion: 18,2% of patients with rheumatoid arthritis using glucocorticoids had gastroduodenal injury on gastroduodenal endoscopy.

Article Details

Keywords

rheumatoid arthritis, glucocorticoid, the modified Lanza score

References

1. Neeck G. Fifty years of experience with cortisone therapy in the study and treatment of rheumatoid arthritis. Annals of the New York Academy of Sciences. 2002;966(1):28-38.
2. Overman RA, Yeh J-Y, Deal CL. Prevalence of oral glucocorticoid usage in the United States: A general population perspective. Arthritis Care & Research. 2013;65(2):294-298. doi:10.1002/acr.21796
3. Naito Y, Yoshikawa T, Iinuma S, et al. Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study. Dig Dis Sci. 1998;43(9 Suppl):83S-89S.
4. Nguyến Chí Thành. Nghiên cứu tình trạng sử dụng và hiểu biết của bệnh nhân viêm khớp dạng thấp về thuốc corticoid. Published online 2017.
5. Zhang Y, Li H, Wu N, Dong X, Zheng Y. Retrospective study of the clinical characteristics and risk factors of rheumatoid arthritis-associated interstitial lung disease. Clin Rheumatol. 2017; 36(4):817-823. doi:10.1007/s10067-017-3561-5
6. Nguyễn Thị Ngọc Lan. Nghiên cứu tổn thương dạ dày tá tràng ở bệnh nhân mắc bệnh khớp điều trị thuốc chống viêm không Steroid. Published online 2003.
7. da Mota LMH, dos Santos Neto LL, de Carvalho JF, et al. The presence of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor on patients with rheumatoid arthritis (RA) does not interfere with the chance of clinical remission in a follow-up of 3 years. Rheumatol Int. 2012;32(12):3807-3812. doi:10.1007/s00296-011-2260-9
8. Tsujimoto S, Mokuda S, Matoba K, et al. The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis. Pagnini C, ed. PLoS ONE. 2018;13(7):e0200023. doi:10.1371/ journal.pone.0200023
9. Matsukawa Y, Aoki M, Nishinarita S, et al. Prevalence of Helicobacter pylori in NSAID users with gastric ulcer. Rheumatology. 2003;42(8):947-950. doi:10.1093/rheumatology/keg258
10. Cheatum DE, Arvanitakis C, Gumpel M, Stead H, Steven Geis G. An endoscopic study of gastroduodenal lesions induced by nonsteroidal anti-inflammatory drugs. Clinical Therapeutics. 1999;21(6):992-1003. doi:10.1016/S0149-2918 (99)80020-4