NGHIÊN CỨU TÁC DỤNG KHÔNG MONG MUỐN CỦA KETAMIN 0,2MG/KG TIÊM TĨNH MẠCH DỰ PHÒNG RUN SAU GÂY TÊ TUỶ SỐNG MỔ LẤY THAI

Abstract

Objective: To evaluate the effects on certain circulatory and respiratory parameters, as well as the adverse effects of intravenous ketamine 0.2 mg/kg for the prophylaxis of shivering after spinal anesthesia for cesarean section. Subjects and Methods: This is a prospective, randomized clinical trial comparing two groups: 50 patients receiving intravenous ketamine 0.2 mg/kg (Group K) and 50 patients receiving intravenous ondansetron 4 mg (Group O), conducted at Military Hospital 354 from December 2022 to June 2023. Results: The body temperature of patients at 20 minutes after spinal anesthesia was significantly lower in Group O than in Group K. The postoperative body temperature at minute 0 was also significantly lower in Group O than in Group K. Body temperatures at all time points during and after surgery remained within normal limits. Bradycardia occurred in 18% of patients in Group O and 14% in Group K. Intraoperative hypotension was observed in 88% of patients in Group O and 84% in Group K. The main adverse effects in Group O were nausea and vomiting (2%), while in Group K, they were nausea and vomiting (12%) and hallucinations (8%). There were no significant differences between the two groups regarding changes in blood pressure, heart rate, respiratory rate, or SPO2. Conclusion: Ketamine has minimal effects on circulation and respiration, with some mild, transient, and manageable adverse effects.