ĐÁNH GIÁ TÍNH THẤM MÔ TRÊN CỘNG HƯỞNG TỪ TIÊM THUỐC ĐỘNG HỌC TRONG CHẨN ĐOÁN UNG THƯ TUYẾN TIỀN LIỆT

Abstract

Purpose: The aims of this study was to evaluate tissue permeability on dynamic contrast-enhanced MRI in the diagnosis of prostate cancer (PC). Material and Methods: A cross-sectional descriptive study was conducted on 39 patients with suspected PC at Hanoi Medical University Hospital from April 2023 to July 2024. Patients underwent multiparametric prostate MRI with dynamic contrast-enhancement (DCE) pulse sequence to evaluate tissue permeability. Results: Of the total 39 patients enrolled in the study, 51.3% were diagnosed with PC and 48.7% were diagnosed with benign tumors. Most patients diagnosed with PC (95.0%) had limited DWI/ADC diffusion and early enhancement on DCE pulses (90%). Among the tissue permeability parameters, K-trans and Kep are two highly valuable parameters in the diagnosis of PC. At the cut-off of 0.382 for K-trans and 1.146 for Kep, the sensitivity and specificity were 90% and 94.2% for Ktrans, 95% and 94.7% for Kep, respectively. Conclusion: Tissue permeability parameters on dynamic contrast-enhancement MRI have high value in diagnosing prostate cancer.