TÌNH TRẠNG NẢY CHỒI BƯỚU TRONG UNG THƯ TẾ BÀO GAI HỐC MIỆNG

Abstract

Introduction: Tumor budding is a new histopathological marker in several human cancers. Objectives: The aim of this study is to evaluate the grading of tumor budding and its association with the clinico-histopathological features and prognosis of oral squamous cell carcinoma. Methods: A cohort study on 147 cases of oral squamous cell carcinoma treated at the Oncology Hospital in Ho Chi Minh City in 2016 and 2017, examining clinical factors, histopathological grading of malignancy, grading tumor budding, with a five-year survival follow-up. Results: The rates of low, moderate, and high tumor budding in oral cancer were 46.9%, 34.7%, and 18.4%, respectively. Tumor budding was associated with histologic malignancy grade (p<0.001), 5-year overall survival rate (p<0.001), and 5-year overall survival time (p=0.001). Reduced survival prognosis was associated with moderate budding, with an HR of 1.88 (95% CI 1.16–3.05; p=0.01), and high budding, with an HR of 2.56 (95% CI 1.48–3.45; p=0.001). The overall HR for both was 2.09 (95% CI 1.35–3.24; p=0.001). Conclusions: Tumor budding is a potential histopathological factor in the prognosis of oral squamous cell carcinoma. Moderate or high tumor budding is a poor prognostic factor.