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20/12/2024
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Lê, M. S., Đoàn, L. V., Nguyễn, V. P., Nguyễn, T. L., Phạm, V. A. Q., Ngô, Đức Q., & Đào, N. V. H. (2024). PRELIMINARY RESULTS OF ONE-STAGE SURGERY TREATMENT OF CHRONIC OSTEOMYELITIS USING CALCIUM HYDROXYAPATITE IMPREGNATED WITH ANTIBIOTIC: A CASE SERIES. Vietnam Medical Journal, 545(2). https://doi.org/10.51298/vmj.v545i2.12210
PRELIMINARY RESULTS OF ONE-STAGE SURGERY TREATMENT OF CHRONIC OSTEOMYELITIS USING CALCIUM HYDROXYAPATITE IMPREGNATED WITH ANTIBIOTIC: A CASE SERIES
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Abstract
Chronic osteomyelitis is a complex disease and difficult to treat. The effectiveness of two-stage surgery with the first stage of debridement and antibiotic-loaded PMMA cement, the second stage of cement removal and bone grafting has been reported in many studies, but there are still some disadvantages. We performed one-stage surgery for a series of 3 patients with chronic osteomyelitis using calcium hydroxyapatite impregnated with antibiotic. All 3 patients showed preliminary safe and effective results.
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chronic osteomyelitis, one-stage surgery, calcium hydroxyapatite, antibiotic.
References
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8. Jiamton C, Apivatgaroon A, Aunaramwat S, et al. Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study. Antibiotics. 2023;12(6):1049. doi:10.3390/ antibiotics12061049
2. Hw B, Hd G. [Infection prevention and surgical management of deep insidious infection in total endoprosthesis]. Chir Z Alle Geb Oper Medizen. 1972;43(10). Accessed June 18, 2023. https://pubmed.ncbi.nlm.nih.gov/5084870/
3. Grimsrud C, Raven R, Fothergill AW, Kim HT. The in vitro elution characteristics of antifungal-loaded PMMA bone cement and calcium sulfate bone substitute. Orthopedics. 2011; 34(8): e378-381. doi:10.3928/01477447-20110627-05
4. Stańczyk M, van Rietbergen B. Thermal analysis of bone cement polymerisation at the cement-bone interface. J Biomech. 2004;37(12): 1803-1810. doi:10.1016/j.jbiomech.2004.03.002
5. Yamashita Y, Uchida A, Yamakawa T, Shinto Y, Araki N, Kato K. Treatment of chronic osteomyelitis using calcium hydroxyapatite ceramic implants impregnated with antibiotic. Int Orthop. 1998;22(4): 247-251. doi:10.1007/ s002640050252
6. Visani J, Staals EL, Donati D. Treatment of chronic osteomyelitis with antibiotic-loaded bone void filler systems: an experience with hydroxyapatites calcium-sulfate biomaterials. Acta Orthop Belg. 2018;84(1):25-29.
7. Wassif RK, Elkayal M, Shamma RN, Elkheshen SA. Recent advances in the local antibiotics delivery systems for management of osteomyelitis. Drug Deliv. 2021;28(1):2392-2414. doi:10.1080/10717544.2021.1998246
8. Jiamton C, Apivatgaroon A, Aunaramwat S, et al. Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study. Antibiotics. 2023;12(6):1049. doi:10.3390/ antibiotics12061049