CÁC YẾU TỐ LIÊN QUAN ĐẾN VIỆC SỬ DỤNG KHÁNG ĐÔNG KÉO DÀI TRÊN BỆNH NHÂN THUYÊN TẮC HUYẾT KHỐI TĨNH MẠCH ĐIỀU TRỊ NGOẠI TRÚ

Abstract

Introduction: The use of extended anticoagulation in patients with venous thromboembolism (VTE) requires a careful balance between its benefits and the risk of bleeding. Currently, there are limited studies in Vietnam investigating the factors influencing extended anticoagulation therapy. Objective: This study was conducted to assess the factors affecting anticoagulant use for more than 3 months in outpatients with venous thromboembolism treated at the Cardiology Clinic, University Medical Center, Ho Chi Minh City. Subjects: Outpatients with venous thromboembolism treated at the University Medical Center, Ho Chi Minh City, from January 2022 to December 2023. Study design: A retrospective, cross-sectional descriptive study. Results: A total of 220 eligible patients were selected, with a mean age of 63.8 ± 16.4 years. Females made up most of the study population (65.5%), and 52.7% of patients were aged ≥ 65 years. The most common comorbidities were hypertension (52.7%), obesity (32.3%), and diabetes (29.1%). Most patients (93.2%, 205 patients) were treated with anticoagulants for more than 3 months. Logistic regression analysis (both univariate and multivariate) of anthropometric, medical history, clinical, and laboratory factors identified that lobar and/or segmental pulmonary embolism and patients who switched anticoagulants during treatment were two significant factors associated with extended anticoagulant use (>3 months), with odds ratios (OR) of 4.95 and 31.28, respectively. Conclusion: The study shows that lobar and/or segmental pulmonary embolism and patients who changed anticoagulants during treatment are two factors that increase the risk of prolonged use of anticoagulants in patients with VTE.