GIÁ TRỊ CỦA THANG ĐIỂM MELD VÀ MÔ HÌNH AE TRONG DỰ ĐOÁN SUY GAN CẤP TRÊN NỀN MẠN Ở BỆNH NHÂN VIÊM GAN VI RÚT B MẠN ĐỢT BÙNG PHÁT NẶNG

Abstract

Objective: Determine value of MELD score, MELD-Na score and AE model in predicting acute-on-chronic liver failure in patients with severe acute exacerbation of chronic hepatitis B virus infection Material and methods: Cross-sectional descriptive research method with analysis and longitudinal follow-up on 120 patients with severe acute exacerbation of chronic hepatitis B virus infection performed at the Department of Gastroenterology, University of Medicine and Pharmacy Hospital in Ho Chi Minh from January 1^st, 2019 to March 30, 2024. Results: Among 120 patients with severe acute exacerbation, 58 had progression to ACLF within 28 days after admission. The AE model with AUROC = 0.734 (95% CI: 0.642 - 0.825), p < 0.001 is better able to predict the progression of acute-on-chronic liver failure in patients with severe acute exacerbation of chronic hepatitis B virus infection than the MELD score (AUROC = 0.605 (95% CI: 0.503 – 0.706); p < 0.05) and MELD-Na score (AUROC = 0.656 (95% CI: 0.558 – 0.755); p < 0.05). Conclusions: The study showed that the AE model with AUROC = 0.734, p < 0.001 has the ability to predict the progression of acute-on-chronic liver failure in patients with severe acute exacerbation of chronic hepatitis B virus. Therefore, the AE model can be applied in clinical practice, helping to early identify acute-on-chronic liver failure in patients with severe acute exacerbation of chronic hepatitis B virus in order to devise active and predictive treatment strategies.