KHẢO SÁT GIÁ TRỊ CỦA CHỈ SỐ TRIGLYCERIDE - GLUCOSE (TYG) TRONG CHẨN ĐOÁN ĐÁI THÁO ĐƯỜNG THAI KỲ

Abstract

Background: Currently, the diagnosis of gestational diabetes primarily relies on the Oral Glucose Tolerance Test (OGTT). However, the OGTT has certain limitations, such as difficulty in ingestion, propensity to induce nausea and vomiting, the discomfort of multiple blood draws, and being time-consuming. Therefore, finding easily measurable indices that can diagnose more effectively and conveniently is essential. Objective: The study aims to determine the sensitivity, specificity, positive predictive value, negative predictive value, and the area under the receiver operating characteristic (ROC) curve of the TyG index in diagnosing gestational diabetes mellitus (GDM). Methods: The study is a cross-sectional analysis. It involves 375 pregnant women who were between 24 and 28 weeks pregnant and attended the Le Van Thinh Hospital for prenatal care. Results: The prevalence of GDM in the study population was 23.7%. The average TyG index value in the GDM group was 9.2, which was higher than the non-GDM group (average TyG index value of 9.02) with statistical significance (p< 0.001). Using an optimal cutoff value of 8.958, the diagnostic performance for GDM was as follows: Sensitivity: 71.1%, Specificity: 45.4%, Negative predictive value: 84.9%, Positive predictive value: 29.7%, Area under the ROC curve: 0.6021 (95% Cl: 0.5353–0.6689). Conclusion: The TyG index can be used as a screening test for GDM during the 24–28 weeks of pregnancy, especially for pregnant women who decline the oral glucose tolerance test (OGTT) or those who cannot undergo OGTT due to vomiting or other reasons.