TỶ LỆ NHIỄM TRÙNG SƠ SINH SỚM Ở TRẺ CÓ MẸ NHIỄM STREPTOCOCCUS NHÓM B KIỂU HÌNH MLSB CÓ SỬ DỤNG KHÁNG SINH DỰ PHÒNG LÂY NHIỄM TRƯỚC SINH TẠI BỆNH VIỆN HÙNG VƯƠNG

Abstract

Objective: The rate of early neonatal infection in infants whose mothers were infected with group B Streptococcus with the MLSB phenotype who gave birth at Hung Vuong Hospital and used antibiotics to prevent infection before birth. Method: A cross-sectional study describing a survey of 483 pregnant women infected with GBS with the MLSB phenotype who gave birth at Hung Vuong Hospital and used antibiotics to prevent infection at least 4 hours before birth during the period from August 1, 2023 to March 31, 2024. Results: Pregnant women aged 25 - < 30 years old: accounted for the highest rate of 35.61%. Pregnancies with GBS with the MLSB phenotype had a rate of premature rupture of membranes of 18.84%. Ampicillin was the most frequently used antibiotic, accounting for 99.17%. 99.79% of pregnant women infected with GBS with the MLSB phenotype had antibiotic susceptibility results to ampicillin. The number of normal newborns, without signs of infection accounted for (89.86%), the rate of early neonatal sepsis was 10.14% CI 95% (7.46 - 12.82). Only 6 cases of early neonatal sepsis were diagnosed as definite sepsis (with positive blood culture results), accounting for 1.24%. Conclusion: Prophylactic antibiotics are effective in reducing the rate of mother-to-child transmission of GBS and reducing the rate of neonatal infection.