NGHIÊN CỨU NỒNG ĐỘ BETA2 MICROGLOBULIN HUYẾT TƯƠNG BẰNG PHƯƠNG PHÁP MIỄN DỊCH ĐO ĐỘ ĐỤC TRÊN BỆNH NHÂN SUY THẬN MẠN CHẠY THẬN NHÂN TẠO TẠI BỆNH VIỆN THỐNG NHẤT

Abstract

Objective: To study the plasma beta2 microglobulin (β2-M) concentration in patients with chronic kidney disease undergoing hemodialysis using turbidimetric immunoassay. To explore the relationship of β2-M with the inflammatory factor CRP, albumin, and dialysis duration to assess inflammation and nutritional status in patients at Thong Nhat Hospital. Subjects and Methods: A cross-sectional descriptive study on 207 hemodialysis patients from November 2023 to May 2024 at Thong Nhat Hospital. Results: The average β2-M concentration was 22,01 ± 3,25 (mg/l). The prevalence of elevated CRP levels was 44%. β2-M concentration showed a positive correlation with CRP (r = 0,48, p < 0,001).The rate of decreased albumin was 39,1%, with β2-M showing a negative correlation with albumin (r = -0,51, p < 0,0001). Dialysis duration: Under 5 years 57,5%, Over 5 years 22,7%, over 10 years 20,3%, the average dialysis duration was 4,26 ± 5,67 (years), with β2-M showing a positive correlation with dialysis duration (r = 0,4029, p < 0,0001). Conclusion: The β2-M concentration is elevated by 10 times in patients with chronic kidney disease undergoing hemodialysis. β2-M correlates positively with CRP, negatively with albumin, and positively with dialysis duration.