ĐÁNH GIÁ MỨC ĐỘ NẶNG CỦA BỆNH PEMPHIGUS THÔNG THƯỜNG THEO THANG ĐIỂM PEMPHIGUS DISEASE AREA INDEX (PDAI)

Abstract

Purpose: To describe the characteristics of the assessment of severity according to the PDAI score of patients with pemphigus vulgaris and some related factors. Subjects and methods: Describe the progression of 82 patients with mild to severe pemphigus vulgaris according to the PDAI score. To compare the differences in PDAI scores by age, gender, the status of systemic immunosuppressive medicine, and to assess the correlation of PDAI scores with the time of onset. The study was conducted at the National Hospital of Dermatology and Venereology, from March 2023 to February 2024. Results: According to the PDAI score, there were 12,2% of patients with mild disease, 30.49% of patients with moderate disease and 57,32% of patients with severe disease. There was no difference in total PDAI scores, cutaneous PDAI, and mucosal PDAI between age groups 20- 40, 41-60 years and ≥ 60 years (p=0,7447, p=0,8014, p=0,5405, respectively) and gender (p=0,4914, p=0,6900, p=0,1873, respectively). There was no difference in total PDAI, cutaneous PDAI, and mucosal PDAI scores between treated and untreated patients (p=0,114, p=0,5496, p=0,0685, respectively)). There was an inverse correlation between the total PDAI score and the time of onset (r=-0,24, p=0,0267). Conclusion: The PDAI is a reliable and valuable scale in assessing the severity of pemphigus. PDAI is divided by region including skin PDAI, mucosal PDAI for more specific values than only the total PDAI score.