CLINICAL MANIFESTATION AND LABORATORY CHARACTERISTICS OF KLEBSIELLA PNEUMONIAE SEPTICEMIA

Nguyễn Lan Hương1,, Thân Mạnh Hùng2, Lê Văn Nam3
1 Military Institute of Preventive Medicine
2 National Hospital for Tropical Diseases
3 Military Hospital 103

Main Article Content

Abstract

Objectives: To describe some clinical and laboratory characteristics of Klebsiella pneumoniae septicemia. Subjects and methods: Descriptive, cross-sectional, prospective and retrospective study in 48 septicemia patients caused by Klebsiella pneumoniae admitted to 103 Military Hospital from January 2017 to June 2021. Results: Median age: 62.67 ± 12.66  years; male 77,08%; underlying diseases: 72.90%; 10.40% hospital infection; 85.40% identified the path to infection (from respiratory tract 41.46%); 27.08% required surgical intervention during hospital stay; average hospital stay: 16.31±1.37 days; 100% had fever, including sudden fever 100%, high fever 45,80% and 58.30% had chills; 60%% pulse > 90 bpm; 12.50% with septic shock; 61% had pneumonia; 16.90% had respiratory failure; WBC >12G/L was 43.80%; Hb < 120g/l was 86.80%; platelets < 150G/l was 39.50%; PT% < 70% was 53.85%; urea >7.5mmol/L was 47.06%; creatinine ≥ 110µmol/L was 28.21%; total bilirubin > 20µmol/l was 47.83%; 60% had PCT >10ng/ml; 60% had CRP >100mg/L. Conclusion: Septicemia caused by K. pneumoniae has a high rate of the path to infection from the respiratory and digestive tracts, multiple organ disorders, a high rate of septic shock and mortality rate.

Article Details

References

1. Bộ môn Truyền nhiễm - Học viện Quân y (2008). Nhiễm khuẩn huyết, Nhà xuất bản y học.
2. Salomao R (2019). Sepsis Eveloping concepts and challeges.
3. Gustinetti G., Mikulska M. (2016). Bloodstream infections in neutropenic cancer patients: a practical update. Virulence, 7(3), 280-297.
4. Wang G., Zhao G., Chao X., et al. (2020). The characteristic of virulence, biofilm and antibiotic resistance of Klebsiella pneumoniae. International Journal of Environmental Research and Public Health, 17(17), 6278.
5. Nguyễn Thị Phương(2016). Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và yếu tố tiên lượng nặng ở bệnh nhân NKH do Klebsiella, Luận văn Thạc sĩ y học, Học viện Quân y.
6. Trịnh Văn Sơn(2021). Nghiên cứu tính kháng kháng sinh của Klebsiella và E.coli, Luận án Tiến sĩ y học, Viện nghiên cứu khoa học y dược lâm sàng 108.
7. Trần Nhật Minh(2019). Phân tích đặc điểm lâm sàng, vi sinh và phác đồ điều trị nhiễm khuẩn huyết do K. pneumoniae tại khoa hồi sức tích cực bệnh viện Bạch Mai, Luận văn Thạc sĩ Dược học, Đại học dược Hà Nội.
8. Harada S A. K., Yamamoto S, (2019). Clinical and Molecular Characteristics of Klebsiella pneumoniae Isolates Causing Bloodstream Infections in Japan: Occurrence of Hypervirulent Infections in Health Care. J Clin Microbiol.