NGHIÊN CỨU ĐẶC ĐIỂM CHỈ SỐ ANTI-MULLERIAN HORMONE (AMH), ANTRAL FOLLICLE COUNT (AFC), OVARIAN RESPONSE PREDICTION INDEX (ORPI) TRÊN PHỤ NỮ ĐƯỢC CHỈ ĐỊNH IVF TẠI BỆNH VIỆN QUỐC TẾ SẢN NHI HẢI PHÒNG

Abstract

Objective: To determine the relationship of AMH, AFC and ORPI with ovarian response to GnRH antagonist protocol in women undergoing IVF at Hai Phong International Hospital of Obstetrics, Gynecology and Pediatrics. Subjects and methods: A cross-sectional study was conducted on 480 women undergoing IVF at Hai Phong International Hospital of Obstetrics, Gynecology and Pediatrics from January 2022 to December 2023. All study subjects underwent AFC, AMH, and ORPI procedures. Results: The mean age was 35.02 ± 4.49. AMH, AFC and ORPI were positively correlated with the number of oocytes retrieved and fertilized (p < 0.01). ORPI had the best predictive ability for ovarian response (AUC = 0.828 for hyper-response, AUC = 0.806 for poor response). The cut-off values for predicting poor and hyper-response for AMH, AFC and ORPI were 1.735 and 3.130 (ng/mL); 10.5 and 12.5 (antral follicles); 0.739 and 1.088 (AMH*AFC/Age). Conclusion: AMH, AFC and ORPI are reliable predictors of ovarian response in women undergoing IVF. ORPI has high potential for clinical application.