ĐẶC ĐIỂM MỘT SỐ CHỈ SỐ HUYẾT HỌC Ở BỆNH NHÂN LUPUS MANG THAI TẠI BỆNH VIỆN BẠCH MAI GIAI ĐOẠN 2020 - 2021

Abstract

Objects: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease and hematological parameters have been reported to useful to assessing systemic inflammation response, disease activity as well as in predicting some organs damage and the occurrence of disease. However, pregnancy effects significantly on these indicators. Therefore, this study aims to understand the change of these indices and their relationship with disease activity during pregnancy. Materials and methods: The cross sectional study involving 82 pregnant SLE patients and the control groups include 40 nonpregnant SLE patients and 30 healthy pregnancies.  Assess disease activity according to the SLEPDAI. The hematological indices are evaluated including hemoglobin concentration, platelet, neutrophil, lymphocyte count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR). Results: Relationship with disease activity during pregnancy, SLEPDAI score was correlated with hemoglobin (r = -0.609), platelet count (r = -0.280), lymphocyte (r = -0.222) and NLR (r = 0.343) but not correlated with PLR. Multivariate linear regression analysis showed that hemoglobin concentration was an independent factor affecting the SLEPDAI score (β = -0.098; p = 0.001). In pregnant lupus patients, NLR (3.96) was elevated compared with the nonpregnant lupus group (2.91) but was not different from that of healthy pregnancies (3.51). PLR (159.66) was not different from the non-pregnant lupus group (175.09) but significantly increased compared with healthy pregnancies (106.34). In the prediction of SLE during pregnancy, AUC value of NLR and PLR were 0.627 (95%CI: 0.519 - 0.735; p = 0.040) and 0.729 (95%CI: 0.627 – 0.822; p < 0.001), respectively. Conclusions: Hemoglobin, NLR and PLR may be indicators of systemic inflammation in SLE during pregnancy.