ĐÁNH GIÁ MỘT SỐ YẾU TỐ TIÊN LƯỢNG TỬ VONG Ở TRẺ SƠ SINH VIÊM MÀNG NÃO DO VI KHUẨN

Abstract

Objective: To evaluate some factors predicting mortality in neonatal bacterial meningitis. Subjects and methods: Cross-sectional descriptive study of 21/123 neonates diagnosed with bacterial meningitis who died at the Neonatal Center - National Children's Hospital during the study period from May 1, 2021 to October 30, 2023. Results: The overall mortality rate was 17.1%, in which the mortality rate of boys was higher than that of girls (76.2% vs. 23.8%), premature birth was higher than full-term birth (76.2% vs. 23.8%). 71.4% of the deceased patients were in the late-onset bacterial meningitis group. K. pneumoniae and S. aureus were the two most common causes of death. Multivariate analysis showed that two predictors of death were low birth weight < 2500 grams (0R = 13.38, 95% CI 1.08 – 165.52) and low peripheral blood leukocyte count < 5,000 x 10 9/l (0R = 5.34, 95% CI 1.24 – 23.5). Conclusion: The mortality rate due to infectious meningitis in newborns is still high (17.1%), children with low birth weight < 2500 grams and low blood leukocyte count < 5,000 x 10 9/l are two factors that significantly increase the risk in the group of sick children with p < 0.05