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Date Published: 24/10/2021
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DOI: https://doi.org/10.51298/vmj.v506i2.1257
Issue
Vol. 506 No. 2 (2021)
Section
Các bài báo
How to Cite
Trường Giang, Đào ., Việt Tú, T. ., & Hồng Bàng, M. . (2021). STUDY THE TREATMENT RESULTS OF DECOMPENSATED CIRRHOSIS CAUSED BY HEPATITIS B VIRUS BY BONE MARROW STEM CELL TRANSPLANTATION. Vietnam Medical Journal, 506(2). https://doi.org/10.51298/vmj.v506i2.1257

STUDY THE TREATMENT RESULTS OF DECOMPENSATED CIRRHOSIS CAUSED BY HEPATITIS B VIRUS BY BONE MARROW STEM CELL TRANSPLANTATION

Đào Trường Giang1,, Trần Việt Tú1, Mai Hồng Bàng2
1 108 Military Central Hospital
2 Vietnam Military Medical University

Main Article Content

Abstract

Objectives: To evaluate the effectiveness of autologous bone marrow stem cell transplantation for the treatment of hepatitis B decompensated cirrhosis. Subjects and methods: 29 patients with hepatitis B virus decompensated cirrhosis received bone marrow stem cells transplantation treatment, from June 2016 to August 2019 and general regimen treatment for patients with cirrhosis. Collect 300ml of bone marrow fluid, then filter the mononuclear cell mass, then inject into the liver through hepatic artery. The patients were followed up for 12 months and efficacy was assessed based on laboratory tests and Child-Pugh and MELD scores at 6 and 12 months. Results: serum albumin levels had statistically significant improvement at all time points of 6, 12months. Child score decreased statistically with p < 0.05; MELD score decreased, but the difference was not statistically significant, with p > 0.05. The difference in the Child-Pugh classification rate at 6 months was statistically significant compared with baseline, with p < 0.05. Conclusion: Stem cell transplantation in cirrhotic patients initially improves liver function, Child-Pugh score.

Article Details

Keywords

cirrhosis, stem cells transplantation, bone marrow, hepatitis B virus

References

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