TREATMENT OUTCOMES OF ENDOMETRIAL CANCER STAGES I AND II AT PATIENTS UNDER 40 YEARS OLD AT NATIONAL CANCER HOSPITAL

Thành Đạt Phạm, Trí Chinh Lê, Hồng Thăng Vũ, Thành Long Trần, Việt Hoàng Trần

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Abstract

Objective: This study aims to evaluate the clinical and paraclinical characteristics and assess the treatment outcomes of patients with endometrial cancer stages I and II who are under 40 years old at Viet Nam National Cancer Hospital. Subjects and Methods: A retrospective descriptive study was conducted involving 51 patients diagnosed with endometrial cancer at FIGO stages I and II, treated at Viet Nam National Cancer Hospital from January 2017 to December 2023. Results: The average age of the patients was 35.29 ± 4.30 years, with 45.1% having a history related to infertility treatment,33.3% of the patients were diagnosed with polycystic ovary syndrome, and the obesity prevalence was 25.5%. Endometrial adenocarcinoma was the predominant histological type, accounting for 98.04%. The majority of patients were classified as FIGO stage IA (70.6%), followed by stage IB (11.8%) and stage II (17.6%). Postoperatively, 66.7% of patients were discharged for regular follow-up, 25.5% required adjuvant radiotherapy, and 7.8% underwent chemoradiotherapy. The rate of ovarian preservation was 33.3%. The mean overall survival (OS) time was 84.2 ± 3.1 months, and the mean disease-free survival (DFS) time was 82.3 ± 3.6 months.The OS rate at 3 years was 94.5%, and at 5 years it was 94.5%; the DFS rate was 95.3% at 3 years and 91.3% at 5 years. Factors Influencing Overall Survival: Histological grade (p < 0.0001), disease stage (p < 0.0001), lymphatic invasion (p = 0.022), and depth of myometrial invasion (p = 0.033) were statistically significant. Ovarian preservation did not significantly impact OS (p = 0.215). Conclusion: Early-stage endometrial cancer in patients under 40 years is frequently associated with infertility, obesity, and polycystic ovary syndrome, and it has a favorable prognosis. Factors such as histological grade, myometrial invasion, lymphatic invasion, and disease stage significantly affect survival outcomes. Ovarian preservation in young women with early-stage endometrial cancer does not influence overall survival.

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References

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