RELATIONSHIP BETWEEN SERUM FGA mRNA LEVELS WITH CLINICAL CHARACTERISTICS AND RISK FACTORS IN HEPATOCELLULAR CARCINOMA PATIENTS
Main Article Content
Abstract
Objective: To investigate the relationship between plasma Fibrinogen Chain A mRNA levels and several clinical characteristics and risk factors in patients with hepatocellular carcinoma (HCC). Subjects and methods: Cross-sectional study of 131 patients diagnosed with HCC at Military Hospital 103 from May 2020 to June 2024. Determination of plasma FGA mRNA levels by Semi-nested Realtime-RT PCR technique and survey of correlation with clinical characteristics. Results: There was no difference in FGA mRNA expression level between different risk factor groups and other clinical symptoms, except that there was a difference in FGA mRNA level with fever, p < 0.05. Conclusion: Serum FGA mRNA level was associated with fever. There was no correlation between FGA mRNA and risk factors and other clinical symptoms in HCC patients.
Article Details
Keywords
Hepatocellular carcinoma, FGA mRNA
References

2. Singal A. G., Llovet J. M., Yarchoan M., et al. (2023). AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology, 78(6): 1922-65.

3. Kudo M., Kawamura Y., Hasegawa K., et al. (2021). Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update. Liver Cancer, 10(3): 181-223.

4. Roskams-Hieter B., Kim H.J., Anur P., et al. (2022). Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies. NPJ Precis Oncol, 6(1): 28.

5. Bộ Y tế (2020). Hướng dẫn chẩn đoán và điều trị ung thư biểu mô tế bào gan, Hà Nội.

6. Zanetto A., Campello E., Spiezia L., et al. (2018). Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma. Cancers (Basel), 10(11).

7. Zhang X., Long Q. (2017). Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients. Medicine (Baltimore), 96(17): e6694.

8. Wang X.P., Mao M.J., He Z.L., et al. (2017). A retrospective discussion of the prognostic value of combining prothrombin time(PT) and fibrinogen (Fbg) in patients with Hepatocellular carcinoma. J Cancer, 8(11): 2079-87.
