COMPARISON OF THE EFFECT OF PREVENTING HYPOTENSION DURING ANESTHESIA OF NOREPINEPHRINE-PROPOFOL AND PHENYLEPHRINE-PROPOFOL IN THE ELDERLY

Nguyễn An Lê, Hoàng Phương Vũ

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Abstract

Objective: Comparison of changes in blood pressure and heart rate in elderly patients during induction of anesthesia with propofol mixed with phenylephrine versus propofol mixed with norepinephrine. Methods: Randomized controlled clinical intervention trial. Results: The study was conducted on 200 patients divided into 2 groups (each group had 100 patients), one group used the anesthetic Norepinephrine-Propofol (NE), one group used the anesthetic Phenylephrine-Propofol (PE). The two groups of patients in the study had similar characteristics in terms of age, gender, and place of residence. Blood pressure and heart rate of the two groups of patients were not different before anesthesia. At 1-2-3-5 minutes after propofol injection, systolic blood pressure, diastolic blood pressure, and mean blood pressure of the group using NE were lower than those of the group using PE. The heart rate of the group of patients using NE decreased more than that of the group of patients using PE at 1-2-3-5 minutes after propofol injection, 1 minute, 5 minutes after intubation. Conclusions: Patients using NE had more hypotension than patients using PE, however patients using PE had a greater reduction in heart rate than patients using NE.

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