SURVEY OF CLINICAL AND PARACLINICAL CHARACTERISTICS OF PATIENTS WITH DRUG-INDUCED HEPATITIS
Main Article Content
Abstract
Objectives: Survey on the clinical, paraclinical characteristics of the patients with hepatitis by traditional medicine at the Hanoi Medical University Hospital. Subjects and methods: A cross-sectional descriptive study on 58 patients diagnosed with Hepatitis is caused by Traditional medicine at the Department Of Internal Medicine, Hanoi Medical University Hospital from 2019 to 2024. Results: Female/male ratio: 67,2%/32,8%, mean age: 52,09±13,75. Reason for admission: jaundice was the most common: 43,1%, followed by fatique: 17,2%. Common clinical symptoms are: fatique: 65,5%, jaundice:60%. The mean AST/ALT: 450 ± 42,74/670 ± 57,10 (U/L), the mean total Billirubin: 112,20 ± 16,84 μmol/l, the patient with PT< 70%: 8,62%, the patients with INR ≥ 1.2: 15,52%. Types of liver injury: Necrotic:84,50%, Cholestatic: 3,45%, Mixed form: 12,05%. Causes of the Hepatitis is caused by traditional medicine:67,23%.
Article Details
Keywords
Drug-induced liver injury (DILI), Roussel Uclaf Causality Assessment Method (RUCAM), Hepatitis is caused by Traditional Medicine
References
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2. Anne M Larson, MD. Drug-induced liver injury - UpToDate. Accessed June 20, 2023. https://www.uptodate.com/contents/drug-induced-liver-injury?search=relationship%20 between%20daily%20Dose%20of%20oral%20medications%20and%20Idiosyncratic%20Drug-Induced%20Liver%20Injury&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1

3. Devarbhavi H. Drug‐Induced Liver Injury Unique to India. Clin Liver Dis (Hoboken). 2021;18(3): 108-110. doi:10.1002/cld.1120


4. Nguyễn Thị Phương Nga. RESEARCH ON DRUG-INDUCED LIVER DAMAGE AT THE DIGESTIVE HEPAROSCOPIC CENTER - BACH MAI HOSPITAL. Accessed October 3, 2024. https://tapchiyhocvietnam.vn/index.php/vmj/article/view/7628/6747

5. Phùng Thị Hằng. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và mô bệnh học của tổn thương gan do thuốc. 2011. (luận văn tốt nghiệp).

6. Björnsson ES, Bergmann OM, Björnsson HK, Kvaran RB, Olafsson S. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144(7):1419-1425, 1425.e1-3; quiz e19-20. doi:10.1053/ j.gastro.2013.02.006


7. Stephens C, Robles-Diaz M, Medina-Caliz I, et al. Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry. J Hepatol. 2021;75(1):86-97. doi:10. 1016/j.jhep.2021.01.029


8. Park JH, Hong S, Jun DW, et al. Prevalence and clinical characteristics of antibiotics associated drug induced liver injury. Ann Transl Med. 2021;9(8):642. doi:10.21037/atm-20-5144


9. Leise MD, Poterucha JJ, Talwalkar JA. Drug-induced liver injury. Mayo Clin Proc. 2014;89(1): 95-106. doi:10.1016/j.mayocp. 2013.09.016


10. Phùng Thị Hằng. Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và mô bệnh học của tổn thương gan do thuốc. Luận văn tốt nghiệp bác sĩ chuyên khoa cấp II. Đại học Y Hà Nội. 2011. Published online 2011.
