RELATIONSHIP BETWEEN PLASMA CERULOPLASMIN mRNA LEVEL AND TUMOR CHARACTERISTICS ON COMPUTERIZED TOMOGRAPHY IN HEPATOCELLULAR CARCINOMA PATIENTS
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Abstract
Objective: To investigate the relationship between plasma Ceruloplasmin mRNA expression levels and tumor characteristics on computed tomography (CT) in patients with hepatocellular carcinoma (HCC). Subjects and methods: Cross-sectional study of 131 patients diagnosed with HCC at Hospital 103. Quantification of CP mRNA level using Semi-nested Realtime-RT PCR and investigation of the relationship with tumor characteristics on CT in patients with HCC. Results: There was a weak correlation between CP mRNA level and tumor diameter (rho = 0.19; p < 0.05) and relationship with portal vein thrombosis (CP mRNA level with portal vein invasion group was significantly higher than that in the group without portal vein invasion, p < 0.05). There was no correlation between CP mRNA level and tumor number, lymph node metastasis and distant metastasis. Conclusion: The CP mRNA level in plasma of HCC patients is related to tumor diameter and portal vein thrombosis, suggesting that this could be a potential prognostic marker.
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Keywords
Hepatocellular carcinoma, Ceruloplasmin mRNA
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