RELATIONSHIP BETWEEN PLASMA CERULOPLASMIN mRNA LEVEL AND TUMOR CHARACTERISTICS ON COMPUTERIZED TOMOGRAPHY IN HEPATOCELLULAR CARCINOMA PATIENTS

Tuấn Minh Ngô, Xuân Khái Nguyễn, Quang Huy Dương, Hữu Thọ Hồ

Main Article Content

Abstract

Objective: To investigate the relationship between plasma Ceruloplasmin mRNA expression levels and tumor characteristics on computed tomography (CT) in patients with hepatocellular carcinoma (HCC). Subjects and methods: Cross-sectional study of 131 patients diagnosed with HCC at Hospital 103. Quantification of CP mRNA level using Semi-nested Realtime-RT PCR and investigation of the relationship with tumor characteristics on CT in patients with HCC. Results: There was a weak correlation between CP mRNA level and tumor diameter (rho = 0.19; p < 0.05) and relationship with portal vein thrombosis (CP mRNA level with portal vein invasion group was significantly higher than that in the group without portal vein invasion, p < 0.05). There was no correlation between CP mRNA level and tumor number, lymph node metastasis and distant metastasis. Conclusion: The CP mRNA level in plasma of HCC patients is related to tumor diameter and portal vein thrombosis, suggesting that this could be a potential prognostic marker.

Article Details

References

Bray F., Laversanne M., Sung H., et al. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 74(3): 229-63.
2. Singal A. G., Llovet J. M., Yarchoan M., et al. (2023). AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology, 78(6): 1922-65.
3. Kudo M., Kawamura Y., Hasegawa K., et al. (2021). Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update. Liver Cancer, 10(3): 181-223.
4. Roskams-Hieter B., Kim H. J., Anur P., et al. (2022). Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies. NPJ Precis Oncol, 6(1): 28.
5. Hu J., Gao Z. (2014). Data-based core genes screening for Hepatocellular Carcinoma. 2014 9th IEEE Conference on Industrial Electronics and Applications: 1102-7.
6. Joachim J. H., Mehta K. J. (2022). Hepcidin in hepatocellular carcinoma. Br J Cancer, 127(2): 185-92.
7. Mukhopadhyay C. K., Attieh Z. K., Fox P. L. (1998). Role of ceruloplasmin in cellular iron uptake. Science, 279(5351): 714-7.
8. Tseng H. H., Chang J. G., Hwang Y. H., et al. (2009). Expression of hepcidin and other iron-regulatory genes in human hepatocellular carcinoma and its clinical implications. J Cancer Res Clin Oncol, 135(10): 1413-20.