CORRELATION BETWEEN PERIPAPILLARY MICROVASCULAR DENSITY AND VISUAL FIELD DAMAGE IN PATIENTS WITH MODERATE AND ADVANCED PRIMARY OPEN-ANGLE GLAUCOMA

Kim Thành Đoàn, Thanh Nghiệp Trang, Võ Mai Quyên Huỳnh, Võ Đăng Khoa Nguyễn

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Abstract

Objective: To assess the correlation of parameters of peripapillary vessel density and 24-2 visual field in eyes with moderate and advanced POAG. Methods: In this observational, cross-sectional study, 74 eyes of 56 patients diagnosed with moderate and severe primary open-angle glaucoma at Ho Chi Minh City Eye Hospital from October 1, 2023 to October 1, 2024 were enrolled. All eyes were divided into 2 groups: moderate primary open-angle glaucoma (32 eyes) and severe primary open-angle glaucoma (32 eyes), based on the Hodapp-Parish-Anderson grading scale. At the time of examination or hospitalization, patients were evaluated for the indices of Peripapillary vascular density (VD) by OCTA, Retinal nerve fiber layer thickness (RNFL) and Ganglion cell complex thickness (GCC) by OCT, Mean Deviation (MD), Mean Sensitivity (MS), Pattern standard deviation (PSD) on the 24-2 Humphrey visual field. The correlation between structural and vascular indices and visual field parameters was tested using Pearson regression. Results: The patients had a mean age of 54.88 ± 15.32 years and a mean MD of -16.32 ± 8.57 dB. The mean peripapillary vascular density (VD) of the study sample, moderate POAG group and severe POAG group were 40.93 ± 3.70%, 43.11 ± 3.27 and 38.75 ± 2.71%, respectively. Between the moderate and severe POAG groups, there was a statistically significant difference in all vascular and structural indices measured by OCT and OCTA (p < 0.05). Among the structural and vascular parameters, superior VD, peripapillary VD, and superior RNFL were the indices with the strongest correlations with MD (r = 0.728, 0.669 and 0.664, respectively; p < 0.001). Conclusion: In moderate and severe POAG eyes, there was a good correlation between total and regional peripapillary vascular density and visual field deficits, especially in the superior quadrant. Overall, VD correlated better with visual field indices than RNFL and GCC thickness

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References

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