ĐÁNH GIÁ NGUY CƠ TIM MẠCH TRÊN BỆNH NHÂN VẢY NẾN TẠI BỆNH VIỆN DA LIỄU TRUNG ƯƠNG

Abstract

Objectives: To assesscardiovascular riskin psoriasis patients by describing current risk factors and estimating 10 year risk of cardiovascular disease (CVD) by using the Framingham risk score (FRS). Subjects and methods: A descriptive cross – sectional study was carried out among  306 psoriasis patients and 306 patients diagnosed with common skin diseases, from 8/2020 to 8/2021 at the National hospital of Dermatology and Venereology. Risk factors of CVD such as smoking, alcohol consumtion, stress, lack of physical activity, overweight/obersity, hypertension, diabetes, dyslipidemia were described and compared between the two groups. Age, sex, smoking, systolic blood pressure (mmHg), diabetes, cholesterol and HDL-C (mmol/L) were calculated for FRS using the Framingham Heart program, available at: https://framinghamheartstudy.org/fhs-risk-functions/cardiovascular-disease-10-year-risk. Results: Psoriasis grouphad higher CVD risk factors than the common skin disease group such as smoking (26,1% vs 19%; p = 0,033), stress (46,1% vs 19%; p < 0,01),overweight/obesity (38,6% vs  28,4%; p = 0,008), hypertension (32,4% vs 11,8%; p < 0,01), diabetes (17,3% vs 7,5%; p < 0,01), dyslipidemia (55,9% vs 35,3%; p < 0,01).  Alcohol consumption and lack of physical activity were not significantly different between the psoriasis group and the control group (36,6% vs 32,4%; p = 0,269 and 58,2% vs 56,2%; p = 0,624; respectively). Psoriasis group had a higher FRS in the next 10 years than the control group (12,7 ± 9,5%vs 9,1 ± 6,9%; p < 0,01). The proportion of patients at high risk of CVD was significantly higher among the psoriasis group compared to those among  the control group (23,9% vs 13,1%; p < 0,01). Multiple linear regression analysis showed that psoriasis was a factor that increases cardiovascular risk (regression coefficient 1.79; p < 0.01). Conclusion: Psoriasis patients had higher cardiovascular risk factors than the control group, including smoking, stress, overweight/obesity, hypertension, diabetes, dyslipidemia. The cardiovascular disease 10 year risk estimated by the Framingham risk score was higher in the psoriasis group than in the control group (12.7% vs 9.1%;p< 0.01). In the multiple linear regression model, psoriasis was the factor that increase cardiovascular risk (regression coefficient 1.79; p < 0.01).