KHẢO SÁT NỒNG ĐỘ HORMONE TUYẾN CẬN GIÁP Ở BỆNH NHÂN BỆNH THẬN MẠN LỌC MÁU CHU KỲ TẠI BỆNH VIỆN HỮU NGHỊ ĐA KHOA NGHỆ AN

Abstract

End stage chronic kidney disease (ECKD) has many changes in substances such as calcium, phosphorus and especially hyperparathyroidism, which increases the level of parathyroid hormone (PTH). Objective: to investigate parathyroid hormone levels in patients with chronic renal failure on dialysis. Subjects and methods: A cross-sectional descriptive study. Total 80 participating patients diagnosed with ECKD with eGFR (estimated glomerular filtration rate) < 15 ml/min/1.73m² undergoing dialysis period, from January 2021 to June 2021, at Nghe An General freindship Hospital. Results: The mean age was 50.31 ± 17,031 years old, in which the lowest age was 17 years old and the highest age was 93 years old. There were 49 male patients, 61.3%, and 31 female patients, 38.7%. Most of the patients had anemia (88.8%). eGFR was 13.42 ± 9.03ml/min/1.73m². Blood calcium concentration was 2.12 ± 0.29 mmol/l and PTH was 569.06 ± 608.19 pg/ml. The rate of increase in PTH hormone levels was 57.4% and PTH within normal limits accounted for 21.3%. The rate of hypocalcemia was 37.5%. There was a statistically significant negative correlation between PTH hormone levels and eGFR (r = - 0.409; p < 0.05). Conclusion: Secondary hyperparathyroidism is common in hemodialysis patients and increases with the decline of eGFR.