THE VALUE OF RETICULOCYTE-RELATED INDICES IN PREDICTING IRON DEFICIENCY IN NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS

Như Nghĩa Nguyễn, Thị Hoàng Mỹ Lê, Quang Diệu Lâm

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Abstract

Objectives: To assess the predictive value of reticulocyte indices in identifying iron deficiency among non-dialysis CKD patients. Materials and methods: This cross-sectional analytical study included 100 non-dialysis CKD patients undergoing inpatient treatment at the Department of Nephrology and Hemodialysis, Kien Giang General Hospital, from April 2023 to April 2024. Results: The median values for reticulocyte indices were as follows: RET# (82.8 g/L), Ret% (2.1%), CHr (27.9 pg), CHCMr (23.2 g/L), and Ret_Hb (1.57 g/dL). The area under the ROC curve (AUC) for CHr-MCV was 0.798 (95% CI: 0.712-0.885), which was higher than that for CHr at 0.777 (95% CI: 0.685-0.869), with a statistically significant difference (p=0,048). CHr demonstrated a sensitivity of 78.6% and a specificity of 72.4% at a cut-off value of 28.05. CHr-MCV showed a sensitivity of 76.2% and a specificity of 77.6% at a cut-off value of 0.077. Conclusion: Reticulocyte parameters show potential in predicting iron deficiency among non-dialysis CKD patients, particularly the reticulocyte hemoglobin content (CHr). Combining CHr with the mean corpuscular volume (MCV) may enhance predictive performance.

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References

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