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MICROBIOLOGICAL CHARACTERISTICS OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN AGED 2 TO UNDER 24 MONTHS WITH A HISTORY OF PREMATURITY AT CHILDREN’S HOSPITAL 1
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Abstract
Objective: To survey the prevalence of epidemiological, clinical, laboratory findings, and microbiology in children aged 2 to under 24 months with a history of prematurity, hospitalized for community-acquired pneumonia (CAP) at Children’s Hospital 1. Materials and method: This is a prospective, cross-sectional, descriptive study with analysis of 120 cases of CAP requiring hospitalization, treated at the Respiratory and Infectious Diseases ICU Departments of Children’s Hospital 1 from September 2023 to July 2024. Nasal tracheal aspirates (NTA) were collected and subjected to multi-pathogen PCR (Polymerase Chain Reaction) for lower respiratory infections. Results: From September 2023 to July 2024, 120 cases met the inclusion criteria for the study. The findings were as follows: Gestational age: mainly >32 weeks (67.5%). Nutritional status: Moderate malnutrition (18.3%), severe malnutrition (19.2%). Comorbidities: The most common was bronchopulmonary dysplasia (20%), followed by gastroesophageal reflux disease (17.1%) and asthma (11.4%). A significant proportion (52.5%) had a history of prior hospitalization for pneumonia. Bacterial pathogens from NTA cultures: Streptococcus pneumoniae was the most prevalent (26.5%), followed by Escherichia coli (17.6%), both of which exhibited ESBL and AmpC resistance genes. Bacterial pathogens from RT-PCR: Streptococcus pneumoniae (37.6%), Escherichia coli (36.8%), Klebsiella pneumonia (22.2%), Acinetobacter spp (22.2%), Haemophilus influenzae non type B (12%), MRSA (8.5%), Mycoplasma pneumoniae (6.8%). Viral pathogens from RT-PCR: CMV (21.4%) and RSV (19.7%) were the most frequently detected, followed by rhinovirus (16.2%), adenovirus (10.3%), and parainfluenza 3 (10.3%). Conclusion: Streptococcus pneumonia infection remained the highest in the study population, followed by E. coli, K. pneumonia and Acinetobacter spp. The most common viral agents were CMV, RSV and rhinovirus.
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Keywords
prematurity, community-acquired pneumonia, microbiology.
References
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