ĐÁNH GIÁ TƯƠNG QUAN MẬT ĐỘ MẠCH MÁU VÙNG HOÀNG ĐIỂM VỚI TỔN THƯƠNG THỊ TRƯỜNG TRÊN BỆNH NHÂN GLAUCOMA GÓC MỞ NGUYÊN PHÁT CẬN THỊ NẶNG

Abstract

Purpose: To evaluate the macular vascular density (VD) and correlation between macular VD and visual field defect in patients with primary open-angle glaucoma (POAG) with high myopia. Methods: This cross-sectional descriptive study was performed on 40 POAG eyes with high myopia. VD, Macular Ganglion Cell–Inner Plexiform Layer Thickness (GCIPLT) were measured and the correlation between global and sectoral macular VD with visual field mean sensitivity (VFMS) in each region according to Rolle’s structure-function map was assessed. The correlation between VFMS and GCIPLT was evaluated and multivariate regression analysis was performed to assess the influence of VD and GCIPLT on VFMS. Results: While the global visual field indexes were correlated with the global macular GCIPLT, the correlation of the global macular VD was only statistically significant with mean deviation. The global, superior, nasal, inferior, temporal macular GCIPLT and the outer global, outer inferior macular VD were correlated with the corresponding VFMS. In the multivariate regression analysis, only the global GCIPLT was significantly correlated with the corresponding VFMS. The VFMS corresponding to the inferior macula was statistically significantly correlated with the outer inferior VD, whereas no correlation with GCIPLT was observed in this region. Conclusion: VD may be a necessary adjunct to GCIPLT to monitor the progression of glaucomatous visual field defects in highly myopic eyes, especially in the outer inferior macula