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Date Published: 05/02/2025
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DOI: https://doi.org/10.51298/vmj.v546i3.12734
Issue
Vol. 546 No. 3 (2025)
Section
Các bài báo
How to Cite
Võ , T. L., Phạm, V. T., Vũ, T. H., Lê, B. C., & Đông, T. H. T. (2025). PREVALENCE OF HYPERVIRULENT KLEBSIELLA PNEUMONIAE STRAINS AND ANTIBIOTIC RESISTANCE GENES IN CASES OF KLEBSIELLA PNEUMONIAE BLOODSTREAM INFECTIONS. Vietnam Medical Journal, 546(3). https://doi.org/10.51298/vmj.v546i3.12734

PREVALENCE OF HYPERVIRULENT KLEBSIELLA PNEUMONIAE STRAINS AND ANTIBIOTIC RESISTANCE GENES IN CASES OF KLEBSIELLA PNEUMONIAE BLOODSTREAM INFECTIONS

Triều Lý Võ , Văn Tân Phạm, Thị Hiếu Vũ, Bửu Châu Lê, Thị Hoài Tâm Đông

Main Article Content

Abstract

Background: A deep understanding of hypervirulent K. pneumoniae and antibiotic resistance genes in cases of K. pneumoniae bloodstream infections played a crucial role in developing treatment strategies against this significant pathogen. Objectives: To determine the prevalence of hypervirulent K. pneumoniae and the prevalence of antibiotic resistance genes in cases of K. pneumoniae bloodstream infections. Methods: An observational study was conducted on patients aged 18 years and older who were admitted to the Hospital for Tropical Diseases between January 2020 and June 2021, with positive cultures of K. pneumoniae from at least one laboratory sample. Results: Among 57 patients with K. pneumoniae bloodstream infections, hypervirulent K. pneumoniae accounted for 8.8% of cases, all of which were community-acquired infections. Antibiotic resistance genes were presented in 24.6% of the cases. The median age was 53 years (IQR: 43-62.5), and 61.4% of the sample was male. Hospital-acquired infections accounted for 14% of the cases. Liver abscesses were the most common site of infections, accounting for 22.8% of cases. Overall mortality was 26.5%. Factors associated with increased mortality were pneumonia (OR 8.7, 95% CI 1.1-67.2) and hospital-acquired infections (OR 23.9, 95% CI 2.2-260.1). Conclusion: Among the 57 K. pneumoniae strains tested genetically, 14 strains carried antibiotic resistance genes, and 5 strains possessed hypervirulent genes. Factors associated with mortality in K. pneumoniae patients included pneumonia and hospital-acquired infections.

Article Details

Keywords

Klebsiella pneumoniae, hypervirulent, antibiotic resistance genes, bloodstream infection.

References

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