EVALUATING THE PROGNOSIS OF MORTALITY ACCORDING TO NSOFA SCORE IN PRETERM NEONATES UNDER 32 WEEKS WITH SEPSIS AT HUNG VUONG HOSPITAL

Hoàng Yến Đỗ, Nguyễn Thế Nguyên Phùng, Thị Thủy Tiên Bùi

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Abstract

Aim: Determine mortality rate and evaluate mortality prognosis according to nSOFA scale in sepsis newborns under 32 weeks. Research subjects and methods: Premature newborns under 32 weeks admitted to the neonatal department of Hung Vuong Hospital from September 2023 to February 2024, longitudinal prospective study, determining the rate of sepsis, the rate of neonatal mortality from sepsis, and determining the nSOFA score within 72 hours after birth, the mortality prognostic value of this score using the ROC curve and the area under the ROC curve (AUC). Results: 180 newborns were collected, 88 neonates had sepsis (48,8%), the mortality rate of children with sepsis was 30,7%, the nSOFA score in 72 hours after birth in the group of children infected with sepsis was higher than the group of children with sepsis survival, the nSOFA scale has predictive value for death with a cutoff point ≥ 5 points, AUC 0.977 CI (0.94-1), specificity 100%, sensitivity 92%, with p < 0.0001. Conclusion: nSOFA score in 72 hours after birth can assess the prognosis of death in newborns 32 weeks of gestation with sepsis nvery well.

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References

Preterm birth: Definitions of prematurity, epidemiology, and risk factors for infant mortality - UpToDate. Accessed March 12, 2023. https://www.uptodate.com/contents/ preterm-birth-definitions-of-prematurity-epidemiology-and-risk-factors-for-infant-mortality?csi=e75c0cd6-50ff-438d-b8fa-3baf2c007833&source=contentShare
2. Horbar JD, Edwards EM, Greenberg LT, et al. Variation in Performance of Neonatal Intensive Care Units in the United States. JAMA Pediatr. 2017; 171(3): e164396. doi:10.1001/ jamapediatrics.2016.4396
3. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315(8): 801-810. doi:10.1001/jama. 2016.0287
4. Matics TJ, Sanchez-Pinto LN. Adaptation and Validation of a Pediatric Sequential Organ Failure Assessment Score and Evaluation of the Sepsis-3 Definitions in Critically Ill Children. JAMA Pediatr. 2017;171(10): e172352. doi:10.1001/ jamapediatrics.2017.2352
5. Fleiss N, Coggins SA, Lewis AN, et al. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Netw Open. 2021;4(2): e2036518. doi:10.1001/ jamanetworkopen.2020.36518
6. Wynn JL, Polin RA. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res. 2020;88(1):85-90. doi:10. 1038/s41390-019-0517-2
7. Wynn JL, Mayampurath A, Carey K, Slattery S, Andrews B, Sanchez-Pinto LN. Multicenter validation of the neonatal sequential organ failure assessment score for prognosis of mortality in the neonatal intensive care unit. J Pediatr. 2021;236: 297-300.e1. doi:10.1016/j.jpeds.2021.05.037
8. Lewis AN, de la Cruz D, Wynn JL, et al. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants with Necrotizing Enterocolitis. Neonatology. 2022;119(3):334-344. doi:10.1159/ 000522560