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Date Published: 05/02/2025
Abstract Views: 258
Views pdf: 165
DOI: https://doi.org/10.51298/vmj.v546i3.12756
Issue
Vol. 546 No. 3 (2025)
Section
Các bài báo
How to Cite
Lê, T. T. N., Suzanne , M. C. B., Nguyễn, A. V., Huỳnh, T. B. H., & Nguyễn, H. N. (2025). INVESTIGATE THE ASSOCIATION BETWEEN FIBRINOGEN CONCENTRATION AND CLOT WAVEFORM ANALYSIS PARAMETERS. Vietnam Medical Journal, 546(3). https://doi.org/10.51298/vmj.v546i3.12756

INVESTIGATE THE ASSOCIATION BETWEEN FIBRINOGEN CONCENTRATION AND CLOT WAVEFORM ANALYSIS PARAMETERS

Thị Tuyết Nga Lê, Monivong Cheanh Beaupha Suzanne , Anh Vũ Nguyễn, Thị Bích Huyền Huỳnh, Hữu Nhân Nguyễn

Main Article Content

Abstract

Introduction: Currently, most coagulation disorder diagnostic tests only provide partial information about the clotting process. However, analyzing clot waveform provides insights into the entire coagulation cascade. This study aims to investigate the correlation between clot waveform analysis (CWA) parameters such as maximum velocity (Min1), maximum acceleration (Min2), and maximum deceleration (Max2), and Fibrinogen levels (FIB), to integrate FIB testing into screening for detecting coagulation disorders. Objectives: 1. Comparison of CWA parameters between the normal FIB group and the abnormal FIB group while APTT and PT are normal. 2. Investigation of the correlation between FIB concentration and CWA parameters. Materials and Methods: A cross-sectional descriptive study with a control group was conducted from October 2022 to July 2023 on 507 samples with normal APTT and PT results at the Hematology Department - Ho Chi Minh City Blood Transfusion and Hematology Hospital. The control group comprised 372 samples with normal FIB levels, while the disease group consisted of 135 samples with abnormal FIB levels. All tests were performed using the automated coagulation analyzer CS-2500 (Siemens Healthcare Diagnostics Products GmbH, Đức). Results: The control group had mean values of Min1: 4.80 ± 0.94 (%/s), Min2: 0.79 ± 0.16 (%/s2), and Max2: 0.66 ± 0.14 (%/s2). The high FIB group showed mean values of Min1: 7.56 ± 1.16 (%/s), Min2: 1.24 ± 0.20 (%/s2), and Max2: 1.04 ± 0.21 (%/s2). The low Fibrinogen group had mean values of Min1: 2.55 ± 0.89 (%/s), Min2: 0.48 ± 0.21 (%/s2), and Max2: 0.38 ± 0.12 (%/s2). Significant differences in CWA parameters were found between normal and abnormal FIB groups (p < 0.001). FIB concentration correlated positively with Min1 (r = 0.942), Min2 (r = 0.919), and Max2 (r = 0.886) (p < 0.001). The regression model predicting Fibrinogen based on Min1 had the highest fit (R2 = 0.887). Conclusion: As Fibrinogen levels rise, so do CWA parameters. Especially Min1, which is the most precise predictor of Fibrinogen concentration.

Article Details

Keywords

Clot waveform analysis, Fibrinogen.

References

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