TƯƠNG QUAN GIỮA ĐỘ DÀY LỚP MỠ THƯỢNG TÂM MẠC VỚI THANG ĐIỂM CHA2DS2-VASC TRONG TIÊN LƯỢNG ĐỘT QUỴ Ở NGƯỜI NHỊP XOANG

Abstract

Background: Increased epicardial fat thickness (EFT) is associated with hypertension, insulin resistance, and thromboembolic events such as stroke, acute coronary syndrome. CHA₂DS₂-VASc is a common score assessing the risk of stroke and thromboembolism in patients with or without atrial fibrillation not related to valvular heart disease. Objective: To determine the correlation between echocardiographic EFT and CHA₂DS₂-VASc score in patients with sinus rhythm. Subjects and research method: A descriptive cross- sectional study was conducted on 260 patients with sinus rhythm hospitalized for all causes, who underwent transthoracic echocardiography at the department of Internal Medicine and Interventional Cardiology, University Medical Center Ho Chi Minh, campus 1, from October 2023 to April 2024. Results: The mean EFT in low and high CHA₂DS₂-VASc groups were 4,1± 1,5 mm and 6,6± 1,9 mm, respectively, with a statistically significant difference (p<0,001). There was a positive, moderate, statistically significant correlation (r=0,6; p<0,001) between EFT and CHA₂DS₂-VASc score. Receiver operating characteristic (ROC) analysis showed that an EFT of 5,3 mm was the optimal cut- off value for predicting the high risk according to the CHA₂DS₂-VASc score, with a sensitivity of 81% and specificity of 82% (Area under the curve AUC= 0,87; 95% CI: 0,82- 0,91). Conclusions: Echocardiographic epicardial fat thickness could provide additional information on assessing thromboembolic risks, and individuals with increased EFT should receive more attention to reduce unfavorable cardiovascular risk factors and the development of future cardiovascular events.