KẾT QUẢ HÓA XẠ TRỊ TIỀN PHẪU UNG THƯ TRỰC TRÀNG TRUNG BÌNH, THẤP BẰNG KỸ THUẬT ĐIỀU BIẾN LIỀU

Abstract

Objectives: To study clinicopathological characteristics of patients with middle and low rectal cancer who received preoperative intensity-modulated radiation therapy and evaluate the treatment results of these patient. Patients and method: A descriptive study of 47 middle and low rectal cancer patiens who were treated with IMRT plus Capecitabine preoperative from March 2021 to June 2024 at Hải Dương Province Hospital. Results: The male/female ratio was 1.6/1. The majority of patients were over 40 years old (95.7%), with the most common age group being 51-70 years old (63.9%). The main reason for hospitalization was bloody mucus in the stool (53.2%). The average time of disease detection was 4.68 ± 2.5 months. The common tumor morphology on endoscopy was the exophytic and ulceration-exophytic type, accounting for 93.6%. Moderately differentiated carcinoma accounted for the highest rate of 72.3%. Highly differentiated carcinoma accounted for 17.0% and poorly differentiated carcinoma was 10.7%. The average CEA concentration before treatment was 5.01±4.7ng/ml. The average CEA concentration after treatment was 3.1±1.6ng/ml. The decrease in CEA before and after treatment was statistically significant with p=0.048. The rate of sphincter-preserving surgery was 16.2%. Response on MRI: 59.6% of tumors decreased in T stage, the change was statistically significant (p<0.001). The rate of partial response on histopathology was 83.7%, the rate of complete response was 9.3%. The median disease-free survival was 25.9 ± 1.7 months. The earliest recurrence time for patients was 4 months, the highest was 31 months. The disease-free survival in stage II was higher than in stage III, the difference was statistically significant (p=0.032).