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NHẬN XÉT KẾT QUẢ CHUYỂN PHÔI ĐÔNG LẠNH NGÀY 5 VÀ NGÀY 6 TẠI BỆNH VIỆN ĐÔNG ĐÔ
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Abstract
Objectives: To compare the outcomes on the 5th-day of frozen blastocyst-stage embryo transfer with those on the 6th-day day at Dong Do Hospital in Hanoi. Methods: A retrospective descriptive study on 442 patients < 35 years of age, with the transfer of very good or good frozen embryos on the 5th or 6th day, without embryo biopsy from January 2022 to April 2024. Results: 345 patients were in the 5th-day embryo transfer group, and 97 patients were in the 6th-day embryo transfer group. For the 5th-day embryo transfer group: the majority transferred 2 embryos with good and fair embryo quality was 45.2% and 54.8%, respectively. For the 6th-day embryo transfer group: the majority had 1 embryo transferred with 13.4% of good embryo and 86.6% of fair embryo. The rate of positive ßHCG in the embryo transfer group on the 5th-day was higher than in the embryo transfer group on 6th-day (85.8% vs 62.7%). The clinical pregnancy rate of the 5th-day embryo transfer group was higher than that of the 6th-day embryo transfer group (71.8% vs. 54.4%). The percentage of the 12-week mark of a pregnancy in the 5th-day embryo transfer group was higher than the day 6th-day embryo transfer group (68.8% vs. 45.4%). Meanwhile the biochemical pregnancy rate on the 6th day of embryo transfer was higher than that on the 5th day (16.5% vs 8.2). The rate of fetal growth arrest between the 2 groups of 5th-day embryo transfer and 6th-day embryo transfer was similar (7.6% vs 7.2%). The 6th-day embryo transfer group had an ectopic pregnancy rate of 2%, while the day 5 embryo transfer group was 0%. The results of the logistic regression model show that two factors have a clear and statistically significant independent influence on the 12-week mark of a pregnancy included number of transfer embryo OR = 4,2; 95%CI: 2,6-6,8) and the quality of embryo (OR = 2,65; 95% CI: 1,6-4,3). Conclusion: Although the pregnancy, clinical pregnancy, and ongoing pregnancy rates were significant higher in the 5th-day group. Therefore, if the patient does not have embryos on the 5th day, a 6th-day embryo transfer is still a good option ensuring high pregnancy rates.
Article Details
Keywords
Blastocyst transfer; Frozen embryo; the 5th-day embryo versus the 6th-day embryo.
References
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