ĐẶC ĐIỂM VI KHUẨN KLEBSIELLA PNEUMONIAE GÂY VIÊM PHỔI TẠI TRUNG TÂM HỒI SỨC TÍCH CỰC BỆNH VIỆN BẠCH MAI GIAI ĐOẠN 2023 – 2024

Abstract

Background: At the Center for Critical Care Medicine of Bach Mai Hospital, infections caused by K. pneumoniae are mainly pneumonia (65.7%) and bacteremia (21.9%)². Recent reports have highlighted a concerning increase in antibiotic resistance of K. pneumoniae, with carbapenem resistance rising significantly from approximately 70% in 2017 to over 80% in 2023. Determining the antibiotic susceptibility profile of K. pneumoniae is critical and holds significant clinical implications. Objective: To assess the antibiotic susceptibility of K. pneumoniae strains isolated from pneumonia patients in the Center for Critical Care Medicine at Bach Mai Hospital during the 2023-2024 period. Subjects and methods: Prospective study on 106 patients diagnosed with K. pneumoniae pneumonia at the Center for Critical Care Medicine of Bach Mai Hospital from 8/2023 to 8/2024. Results: There were 106 patients in the study who were positive for K. pneumoniae and had their antibiotic susceptibility tested. The sensitivity rates to routine antibiotics were: Meropenem (16.13%), Amikacin (38.78%), and Colistin (65.08%). The distribution characteristics of MIC50 and MIC90 with the Carbapenem group were 32µg/ml and >32µg/ml, respectively, with Amikacin were 8µg/ml and >256µg/ml, respectively, with Colistin were <1µg/ml and 64µg/ml. Conclusion: K.pneumoniae bacteria isolated from respiratory tract specimens in pneumonia patients in the study were mostly resistant to conventional antibiotics, the sensitivity rate to Carbapenem group was low, these bacterial strains were also relatively sensitive to Colistin.